Wireless, Fully Implantable and Expandable Electronic System for Bidirectional Electrical Neuromodulation of the Urinary Bladder
- Authors
- Lee, Joong Hoon; Jang, Tae-Min; Shin, Jeong-Woong; Lim, Bong Hee; Rajaram, Kaveti; Han, Won Bae; Ko, Gwan-Jin; Yang, Seung Min; Han, Sungkeun; Kim, Dong-Je; Kang, Heeseok; Lim, Jun Hyeon; Lee, Kyu-Sung; Park, Eunkyoung; Hwang, Suk-Won
- Issue Date
- May-2023
- Publisher
- American Chemical Society
- Keywords
- expandable electronics; fully implantable platform; wireless; electrical stimulation; biomedical devices; urinary bladder; underactive bladder
- Citation
- ACS Nano, v.17, no.9, pp 8511 - 8520
- Pages
- 10
- Journal Title
- ACS Nano
- Volume
- 17
- Number
- 9
- Start Page
- 8511
- End Page
- 8520
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22517
- DOI
- 10.1021/acsnano.3c00755
- ISSN
- 1936-0851
1936-086X
- Abstract
- Current standard clinical options for patients with detrusor underactivity (DUA) or underactive bladder-the inability to release urine naturally-include the use of medications, voiding techniques, and intermittent catheterization, for which the patient inserts a tube directly into the urethra to eliminate urine. Although those are life-saving techniques, there are still unfavorable side effects, including urinary tract infection (UTI), urethritis, irritation, and discomfort. Here, we report a wireless, fully implantable, and expandable electronic complex that enables elaborate management of abnormal bladder function via seamless integrations with the urinary bladder. Such electronics can not only record multiple physiological parameters simultaneously but also provide direct electrical stimulation based on a feedback control system. Uniform distribution of multiple stimulation electrodes via mesh-type geometry realizes low-impedance characteristics, which improves voiding/urination efficiency at the desired times. In vivo evaluations using live, free-moving animal models demonstrate system-level functionality.
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Collections - College of Medical Sciences > Department of Biomedical Mechatronics > 1. Journal Articles
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