Transcranial application of magnetic pulses for improving brain drug delivery efficiency via intranasal injection of magnetic nanoparticles
- Authors
- Ye, Eunbi; Park, Eunkyoung; Kim, Eunseon; Lee, Jung Eun; Yang, Seung Ho; Park, Sung-Min
- Issue Date
- Aug-2023
- Publisher
- 대한의용생체공학회
- Keywords
- Intranasal administration; Transcranial magnetic stimulation; Magnetic force; Magnetic targeted delivery; Magnetic drug targeting
- Citation
- Biomedical Engineering Letters (BMEL), v.13, no.3, pp 417 - 427
- Pages
- 11
- Journal Title
- Biomedical Engineering Letters (BMEL)
- Volume
- 13
- Number
- 3
- Start Page
- 417
- End Page
- 427
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22572
- DOI
- 10.1007/s13534-023-00272-0
- ISSN
- 2093-9868
2093-985X
- Abstract
- As the blood-brain barrier (BBB) hinders efficient drug delivery to the brain, drug delivery via the intranasal pathway, bypassing the BBB, has received considerable attention. However, intranasal administration still has anatomical and physiological limitations, necessitating further solutions to enhance effectiveness. In this study, we used transcranial magnetic stimulation (TMS) on fluorescent magnetic nanoparticles (MNPs) of different sizes (50, 100, and 300 nm) to facilitate MNP's transportation and delivery to the brain parenchyma. To validate this concept, anesthetized rats were intranasally injected with the MNPs, and TMS was applied to the center of the head. As the result, a two-fold increase in brain MNP delivery was achieved using TMS compared with passive intranasal administration. In addition, histological analysis that was performed to investigate the safety revealed no gross or microscopic damages to major organs caused by the nanoparticles. While future studies should establish the delivery conditions in humans, we expect an easy clinical translation in terms of device safety, similar to the use of conventional TMS. The strategy reported herein is the first critical step towards effective drug transportation to the brain.
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Collections - College of Medical Sciences > Department of Biomedical Mechatronics > 1. Journal Articles
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