Rheumatoid factor is associated with severe COVID-19
DC Field | Value | Language |
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dc.contributor.author | Jeong, Hyemin | - |
dc.contributor.author | Baek, Ae Rin | - |
dc.contributor.author | Park, Sung Woo | - |
dc.contributor.author | Kim, Tark | - |
dc.contributor.author | Choo, Eun Ju | - |
dc.contributor.author | Jeon, Chan Hong | - |
dc.date.accessioned | 2023-08-07T03:40:16Z | - |
dc.date.available | 2023-08-07T03:40:16Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 1756-1841 | - |
dc.identifier.issn | 1756-185X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22576 | - |
dc.description.abstract | Aim: Coronavirus disease 2019 (COVID-19) has been proposed as triggering autoimmunity. The aim of this study was to evaluate the presence and clinical significance of autoantibodies in patients with COVID-19.Methods: We retrospectively collected data from 245 patients who were hospitalized for COVID-19. All patients were tested for the presence of antinuclear antibody (ANA), rheumatoid factor (RF), anti-citrullinated peptide antibody (ACPA), and anti-cytoplasmic neutrophil antibody (ANCA). Risk factors for death and critical COVID-19, defined as the need for invasive mechanical ventilation or extracorporeal membrane oxygenation, were analyzed.Results: Ninety (36.7%) patients tested positive for ANA, and 51 (20.8%) patients tested positive for RF. Three patients each (1.2%) tested positive for ACPA and ANCA. RF-positive patients had higher rates of invasive mechanical ventilation and death than RF-negative patients (70.6% vs 28.4%, P < 0.001 and 45.1% vs 18.6%, P < 0.001, respectively). Underlying lung disease, kidney disease, heart disease, quick COVID severity index (qCSI), and lactate dehydrogenase (LDH) were associated with in-hospital death. RF (odds ratio [OR] 7.31, 95% CI 2.50-21.37, P < 0.001), qCSI (OR 1.42, 95% CI 1.19-1.69, P < 0.001), and LDH (OR 1.004, 95% CI 1.002-1.005, P < 0.001) were associated with critical COVID-19. Combination of RF, qCSI, and LDH showed good prognostic value (area under the curve = 0.903, P < 0.001) for critical COVID-19.Conclusions: ANA and RF were frequently detected in COVID-19 patients. RF could be a risk factor for critical COVID-19. The results of this study suggest immune dysfunction contributes to the complications of COVID-19. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Rheumatoid factor is associated with severe COVID-19 | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/1756-185X.14647 | - |
dc.identifier.scopusid | 2-s2.0-85150965796 | - |
dc.identifier.wosid | 000958726100001 | - |
dc.identifier.bibliographicCitation | International Journal of Rheumatic Diseases, v.26, no.5, pp 850 - 861 | - |
dc.citation.title | International Journal of Rheumatic Diseases | - |
dc.citation.volume | 26 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 850 | - |
dc.citation.endPage | 861 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | ANTINUCLEAR ANTIBODIES | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | PNEUMONIA | - |
dc.subject.keywordPlus | INDIVIDUALS | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordAuthor | antinuclear antibody | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | rheumatoid factor | - |
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