Incidence of Pregnancy-Associated Venous Thromboembolism: Second Nationwide Study
- Authors
- Hwang, Hun-Gyu; Lee, Ju Hyun; Bang, Soo-Mee
- Issue Date
- Sep-2023
- Publisher
- Schattauer
- Keywords
- pregnancy; venous thromboembolism; age; cesarean section; multiparity; multifetal pregnancies
- Citation
- Thrombosis and Haemostasis, v.123, no.09, pp 904 - 910
- Pages
- 7
- Journal Title
- Thrombosis and Haemostasis
- Volume
- 123
- Number
- 09
- Start Page
- 904
- End Page
- 910
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/22585
- DOI
- 10.1055/a-2019-0607
- ISSN
- 0340-6245
2567-689X
- Abstract
- Background Pregnancy is a transient risk factor for venous thromboembolism (VTE). This second nationwide study aimed to inspect trend changes in the incidence rate of pregnancy-associated VTE (PA-VTE) during the study period (2014-2018) compared with that reported in a previous study (2006-2010).Methods Using the Korean Health Insurance Review and Assessment Service database, we retrospectively identified all PA-VTE events using both diagnostic and medication codes.Results Of the 124,228 VTE events, 510 (0.4%) cases of PA-VTE were identified in 499 women (median age: 34 years; range: 20-49 years). The incidence rate of PA-VTE/ 10,000 deliveries (PA-VTE/10(4)D) in this second study (2.62) was 3.2 times higher than that in the first study (0.82). In the second study, the PA-VTE/10(4)D ratio of women in their 40s (5.46) was three times higher than that of women in their 20s (1.80) (relative risk: 3.03; 95% confidence interval: 2.04-4.51; p < 0.01). The incidence rate for women in their 40s in the second study was 2.3 times higher than that in the first study. PA-VTE/ 10(4)D cases occurred more frequently in multiparous than in primiparous women, in cesarean section cases compared with vaginal delivery, and in multiple rather than single pregnancies. Most PA-VTE cases occurred during the postpartum period (321/510, 62.9%), of which pulmonary embolism was the most frequently occurring type (231/321, 72%).Conclusion Advanced maternal age, cesarean section, multiparity, and multifetal pregnancies increased the risk of PA-VTE. Obstetricians need to be cautious of VTE, particularly during the postpartum period, in high-risk pregnant patients.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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