The Cellular Prion Protein: A Promising Therapeutic Target for Canceropen access
- Authors
- Go, Gyeongyun; Lee, Sang Hun
- Issue Date
- Dec-2020
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- cellular prion protein; PrP(C); PRNP; cancer; cancer stem cell; targeted cancer therapy
- Citation
- International Journal of Molecular Sciences, v.21, no.23
- Journal Title
- International Journal of Molecular Sciences
- Volume
- 21
- Number
- 23
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2294
- DOI
- 10.3390/ijms21239208
- ISSN
- 1661-6596
1422-0067
- Abstract
- Studies on the cellular prion protein (PrP(C)) have been actively conducted because misfolded PrP(C) is known to cause transmissible spongiform encephalopathies or prion disease. PrP(C) is a glycophosphatidylinositol-anchored cell surface glycoprotein that has been reported to affect several cellular functions such as stress protection, cellular differentiation, mitochondrial homeostasis, circadian rhythm, myelin homeostasis, and immune modulation. Recently, it has also been reported that PrP(C) mediates tumor progression by enhancing the proliferation, metastasis, and drug resistance of cancer cells. In addition, PrP(C) regulates cancer stem cell properties by interacting with cancer stem cell marker proteins. In this review, we summarize how PrP(C) promotes tumor progression in terms of proliferation, metastasis, drug resistance, and cancer stem cell properties. In addition, we discuss strategies to treat tumors by modulating the function and expression of PrP(C) via the regulation of HSPA1L/HIF-1 alpha expression and using an anti-prion antibody.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Biochemistry > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2294)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.