Serum Calprotectin Is a Potential Marker in Patients with Asthmaopen access
- Authors
- Lee, Yun-Gi; Hong, Jisu; Lee, Pureun-Haneul; Lee, Junehyuk; Park, Sung-Woo; Kim, DoJin; Jang, An-Soo
- Issue Date
- 9-Nov-2020
- Publisher
- 대한의학회
- Keywords
- Calprotectin; Asthma; Airway Inflammation
- Citation
- Journal of Korean Medical Science, v.35, no.43
- Journal Title
- Journal of Korean Medical Science
- Volume
- 35
- Number
- 43
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2320
- DOI
- 10.3346/jkms.2020.35.e362
- ISSN
- 1011-8934
1598-6357
- Abstract
- Background: Calprotectin is the major cytosolic protein in neutrophil granulocytes. Although asthma is known to cause eosinophilic inflammation, some patients with asthma have non-eosinophilic inflammation, which is characterized by local neutrophilic inflammation. The aim of this study was to assess calprotectin expression levels in a mouse model of asthma, and to observe the relationship of serum calprotectin level and clinical variables in patients with asthma. Methods: Mice were sensitized and challenged with 10 mu g and 20 mu g of Aspergillus fumigatus, respectively; mice treated with saline were used as a control. The levels of calprotectin were determined using enzyme-linked immunosorbent assay, immunoblotting, and immunohistochemical analysis. The serum levels of calprotectin were also assessed in patients with asthma. The relationship between calprotectin and clinicopathological characteristics was determined. Results: Calprotectin, S100A8, and S100A9 expression was elevated in the mouse lungs, Calprotectin levels were higher in the serum of patients with asthma (n = 33) compared with those of healthy individuals (n = 28). Calprotectin levels correlated with forced expiratory volume in one second/forced vital capacity (r = -0.215, P = 0.043), smoke amount (r = 0.413, P = 0.017), body mass index (r = -0.445, P = 0.000), and blood neutrophil percentage (r = 0.300, P = 0.004) in patients with asthma. Conclusion: Our data suggest that calprotectin could potentially be used as a biomarker for asthma.
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