Successful treatment of a high-risk nonseminomatous germ cell tumor using etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine: A case report
- Authors
- Yun, Jina; Lee, Sang W.; Lim, Sung H.; Kim, Se H.; Kim, Chan K.; Park, Seong K.
- Issue Date
- Nov-2020
- Publisher
- Baishideng Publishing Group Co. Limited
- Keywords
- Antineoplastic combined chemotherapy protocols; Choriocarcinoma; Testicular neoplasms; Cyclophosphamide; Methotrexate; Case report
- Citation
- World Journal of Clinical Cases, v.8, no.21, pp 5334 - 5340
- Pages
- 7
- Journal Title
- World Journal of Clinical Cases
- Volume
- 8
- Number
- 21
- Start Page
- 5334
- End Page
- 5340
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2322
- DOI
- 10.12998/wjcc.v8.i21.5334
- ISSN
- 2307-8960
- Abstract
- BACKGROUND Choriocarcinoma is an infrequent entity and the most aggressive subtype of germ-cell tumors. Because of early metastatic spread and rapid disease progression, choriocarcinoma patients display poor prognosis. Although etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine (EMA-CO) regimen is widely used to treat gestational trophoblastic tumors in females, its role in treating male choriocarcinoma is seldom reported. CASE SUMMARY A 32-year-old man was diagnosed with burned-out primary germ cell tumors (GCT) with retroperitoneum, liver and lung metastases. Biopsy of the liver revealed pure choriocarcinoma. The patient received bleomycin, etoposide, and cisplatin chemotherapy. After two cycles of treatment, response evaluation revealed the mixed response. EMA-CO regimen was used in the second-line therapy. After eight cycles, the patient showed a potentially resectable state and thus, all residual masses were surgically removed. The patient was completely cured, and 10 years later, he is leading a healthy life without complications. CONCLUSION This paper is the first case of high-risk nonseminomatous GCT in a male patient to be successfully treated with the EMA-CO regimen. The EMA-CO regimen can be used actively in patients with high-risk nonseminomatous GCT.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Urology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.