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Recent Advances on the Role of GSK3 beta in the Pathogenesis of Amyotrophic Lateral Sclerosisopen access

Authors
Choi, Hyun-JunCha, Sun JooLee, Jang-WonKim, Hyung-JunKim, Kiyoung
Issue Date
Oct-2020
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
amyotrophic lateral sclerosis; GSK3β neurodegenerative disease
Citation
Brain Sciences, v.10, no.10
Journal Title
Brain Sciences
Volume
10
Number
10
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2432
DOI
10.3390/brainsci10100675
ISSN
2076-3425
Abstract
Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disease characterized by progressive motor neuron degeneration. Although several studies on genes involved in ALS have substantially expanded and improved our understanding of ALS pathogenesis, the exact molecular mechanisms underlying this disease remain poorly understood. Glycogen synthase kinase 3 (GSK3) is a multifunctional serine/threonine-protein kinase that plays a critical role in the regulation of various cellular signaling pathways. Dysregulation of GSK3 beta activity in neuronal cells has been implicated in the pathogenesis of neurodegenerative diseases. Previous research indicates that GSK3 beta inactivation plays a neuroprotective role in ALS pathogenesis. GSK3 beta activity shows an increase in various ALS models and patients. Furthermore, GSK3 beta inhibition can suppress the defective phenotypes caused by SOD, TDP-43, and FUS expression in various models. This review focuses on the most recent studies related to the therapeutic effect of GSK3 beta in ALS and provides an overview of how the dysfunction of GSK3 beta activity contributes to ALS pathogenesis.
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