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Efficacy and safety of lobeglitazone versus sitagliptin as an add-on to metformin in patients with type 2 diabetes with two or more components of metabolic syndrome over 24 weeks

Authors
Kim, Sin GonKim, Kyoung JinYoon, Kun HoChun, Sung WanPark, Kyong SooChoi, Kyung MookLim, SooMok, Ji-OhLee, Hyoung WooSeo, Ji A.Cha, Bong-SooKim, Mi KyungShon, Ho SangChoi, Dong SeopKim, Doo Man
Issue Date
Oct-2020
Publisher
Blackwell Publishing Inc.
Keywords
clinical trial; lobeglitazone; randomized trial; thiazolidinediones; type 2 diabetes
Citation
Diabetes, Obesity and Metabolism, v.22, no.10, pp 1869 - 1873
Pages
5
Journal Title
Diabetes, Obesity and Metabolism
Volume
22
Number
10
Start Page
1869
End Page
1873
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2455
DOI
10.1111/dom.14085
ISSN
1462-8902
1463-1326
Abstract
We aimed to evaluate the efficacy and safety profile of lobeglitazone compared with sitagliptin as an add-on to metformin in patients with type 2 diabetes as well as other components of metabolic syndrome. Patients inadequately controlled by metformin were randomly assigned to lobeglitazone (0.5 mg, n = 121) or sitagliptin (100 mg, n = 126) for 24 weeks. The mean changes in HbA1c of the lobeglitazone and sitagliptin groups were -0.79% and -0.86%, respectively; the between-group difference was 0.08% (95% confidence interval, -0.14% to 0.30%), showing non-inferiority. The proportion of patients having two or more factors of other metabolic syndrome components decreased to a greater extent in the lobeglitazone group than in the sitagliptin group (-11.9% vs. -4.8%;P < .0174). Favourable changes in the lipid metabolism were also observed with lobeglitazone, which had a similar safety profile to sitagliptin. Lobeglitazone was comparable with sitagliptin as an add-on to metformin in terms of efficacy and safety.
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