Assessment of the potential risk of 1,2-hexanediol using phytotoxicity and cytotoxicity testing
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Uhram | - |
dc.contributor.author | Kim, Jieun | - |
dc.date.accessioned | 2021-08-11T08:32:48Z | - |
dc.date.available | 2021-08-11T08:32:48Z | - |
dc.date.issued | 2020-09-15 | - |
dc.identifier.issn | 0147-6513 | - |
dc.identifier.issn | 1090-2414 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2467 | - |
dc.description.abstract | 1,2-Hexanediol is commonly used in the cosmetic industry as a preservative, an emollient, and a moisturizing agent. However, studies on the scientific toxicity of 1,2-hexanediol are limited. In this study, we evaluated the potential toxic effects of 1,2-hexanediol using phytotoxicity and cytotoxicity testing methods. Phytotoxicity tests using Brassica campestris subsp. napes and Latuca sativa L. showed that 1,2-hexanediol significantly inhibited seed germination and root elongation at the lowest concentration (0.1%). Additionally, plants treated with 1,2-hexanediol failed to survive. In cytotoxicity tests, RAW 264.7 and HK-2 cells treated with 1.0% 1,2-Hexanediol showed a significant decline in viability, followed by death. Since most personal care products contain > 2% 1,2-hexanediol, it is highly likely that 1,2-hexanediol is toxic to humans. Moreover, if 1,2-hexanediol enters the human body either via oral intake or through an open wound, it could have critical effects. Furthermore, upon release into the environment, 1,2-hexanediol could cause considerable damage to plants and other organisms. Therefore, further investigation of 1,2-hexanediol is required to prevent toxicity to humans and other living organisms. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academic Press | - |
dc.title | Assessment of the potential risk of 1,2-hexanediol using phytotoxicity and cytotoxicity testing | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.ecoenv.2020.110796 | - |
dc.identifier.scopusid | 2-s2.0-85085682990 | - |
dc.identifier.wosid | 000546898000026 | - |
dc.identifier.bibliographicCitation | Ecotoxicology and Environmental Safety, v.201 | - |
dc.citation.title | Ecotoxicology and Environmental Safety | - |
dc.citation.volume | 201 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | PRESERVATIVES | - |
dc.subject.keywordAuthor | 1,2-Hexanediol | - |
dc.subject.keywordAuthor | CH3(CH2)(3)CH(OH)CH2OH | - |
dc.subject.keywordAuthor | Phytotoxicity | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | RAW 264.7 cells | - |
dc.subject.keywordAuthor | HK-2 cells | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.