Assessment of the potential risk of 1,2-hexanediol using phytotoxicity and cytotoxicity testing
- Authors
- Song, Uhram; Kim, Jieun
- Issue Date
- 15-Sep-2020
- Publisher
- Academic Press
- Keywords
- 1,2-Hexanediol; CH3(CH2)(3)CH(OH)CH2OH; Phytotoxicity; Cytotoxicity; RAW 264.7 cells; HK-2 cells
- Citation
- Ecotoxicology and Environmental Safety, v.201
- Journal Title
- Ecotoxicology and Environmental Safety
- Volume
- 201
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2467
- DOI
- 10.1016/j.ecoenv.2020.110796
- ISSN
- 0147-6513
1090-2414
- Abstract
- 1,2-Hexanediol is commonly used in the cosmetic industry as a preservative, an emollient, and a moisturizing agent. However, studies on the scientific toxicity of 1,2-hexanediol are limited. In this study, we evaluated the potential toxic effects of 1,2-hexanediol using phytotoxicity and cytotoxicity testing methods. Phytotoxicity tests using Brassica campestris subsp. napes and Latuca sativa L. showed that 1,2-hexanediol significantly inhibited seed germination and root elongation at the lowest concentration (0.1%). Additionally, plants treated with 1,2-hexanediol failed to survive. In cytotoxicity tests, RAW 264.7 and HK-2 cells treated with 1.0% 1,2-Hexanediol showed a significant decline in viability, followed by death. Since most personal care products contain > 2% 1,2-hexanediol, it is highly likely that 1,2-hexanediol is toxic to humans. Moreover, if 1,2-hexanediol enters the human body either via oral intake or through an open wound, it could have critical effects. Furthermore, upon release into the environment, 1,2-hexanediol could cause considerable damage to plants and other organisms. Therefore, further investigation of 1,2-hexanediol is required to prevent toxicity to humans and other living organisms.
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Collections - College of Medicine > Department of Clinical Pathology > 1. Journal Articles
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