Severity of foot process effacement is associated with proteinuria in patients with IgA nephropathyopen access
- Authors
- Lee, Ji-Hye; Jang, Si-Hyong; Cho, Nam-Jun; Heo, Nam Hun; Gil, Hyo-Wook; Lee, Eun Young; Moon, Jong-Seok; Park, Samel
- Issue Date
- Sep-2020
- Publisher
- 대한신장학회
- Keywords
- Glomerulonephritis; Immunoglobulin A; Nephropathy; Podocytes; Proteinuria
- Citation
- Kidney Research and Clinical Practice, v.39, no.3, pp 295 - 304
- Pages
- 10
- Journal Title
- Kidney Research and Clinical Practice
- Volume
- 39
- Number
- 3
- Start Page
- 295
- End Page
- 304
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2487
- DOI
- 10.23876/j.krcp.20.017
- ISSN
- 2211-9132
2211-9140
- Abstract
- Background: Proteinuria is a significant risk factor for progression of IgA nephropathy (IgAN) and has a positive correlation with severity of foot process effacement (FPE). We evaluated the relationship of FPE with proteinuria and histologic characteristics, including the Oxford classification. Methods: Patients who underwent renal biopsy and were diagnosed with IgAN at a single center were retrospectively reviewed. Patients aged less than 18 years and those with the possibility of secondary causes were excluded from the study. Subsequently, we evaluated the association between degree of proteinuria, severity of FPE, and histologic characteristics, including the Oxford classification and other immunofluorescence stains. Results: A total of 805 cases of renal biopsy was performed at our institution, and 327 patients were diagnosed with IgAN. Among them, 82 patients were excluded. Severity of FPE had an impact on the degree of proteinuria. Notably, the group with diffuse FPE had more than about 1.3 g/day of urine protein compared to those with rare FPE. Among the histologic characteristics, M1 score and immune deposition of IgG affected severity of FPE (hazard ratios [95% confidence interval], 1.90 [1.10 to 3.26], and 3.77 [1.66 to 8.54], respectively). Conclusion: Severity of FPE had an impact on the degree of proteinuria and may be associated with the pathogenesis of IgAN.
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Collections - Graduate School > Department of Integrated Biomedical Science > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Pathology > 1. Journal Articles
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