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Real-world data on the incidence and risk of Guillain-Barre syndrome following SARS-CoV-2 vaccination: a prospective surveillance studyopen access

Authors
Ha, JongmokPark, SuyeonKang, HyunwookKyung, TaeeunKim, NamohKim, Dong KyuKim, HyeonjoonBae, KihoonSong, Min CheolLee, Kwang JuneLee, EuihoHwang, Beom SeukYoun, JinyoungSeok, Jin MyoungPark, Kunhee
Issue Date
Mar-2023
Publisher
Nature Publishing Group
Citation
Scientific Reports, v.13, no.1
Journal Title
Scientific Reports
Volume
13
Number
1
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25175
DOI
10.1038/s41598-023-30940-1
ISSN
2045-2322
Abstract
Increasing evidence suggests an association between SARS-CoV-2 vaccines and Guillain-Barre syndrome (GBS). Nevertheless, little is understood about the contributing risk factors and clinical characteristics of GBS post SARS-CoV-2 vaccination. In this prospective surveillance study of 38,828,691 SARS-CoV-2 vaccine doses administered from February 2021 to March 2022 in the Gyeonggi Province, South Korea, 55 cases of GBS were reported post vaccination. We estimated the incidence rate of GBS per million doses and the incidence rate ratio for the vaccine dose, mechanism, age, and sex. Additionally, we compared the clinical characteristics of GBS following mRNA-based and viral vector-based vaccinations. The overall incidence of GBS following SARS-CoV-2 vaccination was 1.42 per million doses. Viral vector-based vaccines were associated with a higher risk of GBS. Men were more likely to develop GBS than women. The third dose of vaccine was associated with a lower risk of developing GBS. Classic sensorimotor and pure motor subtypes were the predominant clinical subtypes, and demyelinating type was the predominant electrodiagnostic subtype. The initial dose of viral-vector based vaccine and later doses of mRNA-based vaccine were associated with GBS, respectively. GBS following SARS-CoV-2 vaccination may not be clinically distinct. However, physicians should pay close attention to the classic presentation of GBS in men receiving an initial dose of viral vector-based SARS-CoV-2 vaccines.
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