Interactive tissue reactions of 1064-nm focused picosecond-domain laser and dermal cohesive polydensified matrix hyaluronic acid treatment in in vivo rat skin
- Authors
- Kim, Hee Kyung; Kim, Hyun-Jo; Hong, Jeong Yeon; Park, Jinyoung; Lee, Hee Chul; Lyu, Herin; Cho, Sung Bin
- Issue Date
- Sep-2020
- Publisher
- Blackwell Publishing Inc.
- Keywords
- CD44; cohesive polydensified matrix hyaluronic acid; laser; laser-induced tissue breakdown; neodymium-doped yttrium aluminum garnet; picosecond
- Citation
- Skin Research and Technology, v.26, no.5, pp 683 - 689
- Pages
- 7
- Journal Title
- Skin Research and Technology
- Volume
- 26
- Number
- 5
- Start Page
- 683
- End Page
- 689
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2537
- DOI
- 10.1111/srt.12853
- ISSN
- 0909-752X
1600-0846
- Abstract
- Background Picosecond-domain laser treatment using a microlens array (MLA) or a diffractive optical element (DOE) generates micro-injury zones in the epidermis and upper dermis. Objective To investigate interactive tissue reactions between MLA-type picosecond laser pulses and cohesive polydensified matrix hyaluronic acid (CPMHA) filler in the dermis. Methods In vivo rats with or without CPMHA pretreatment were treated with a 1064-nm picosecond-domain neodymium:yttrium-aluminum-garnet (Nd:YAG) laser using an MLA or DOE. Skin samples were obtained at post-treatment days 1, 10, and 21 and histologically and immunohistochemically analyzed. Results Picosecond-domain Nd:YAG laser treatment with an MLA-type or a DOE-type handpiece generated fractionated zones of pseudo-cystic cavitation along the lower epidermis and/or upper papillary dermis at Day 1. At Day 21, epidermal thickness, dermal fibroblasts, and collagen fibers had increased. Compared to CPMHA-untreated rats, rats pretreated with CPMHA showed marked increases in fibroblasts and collagen fibers in the papillary dermis. Immunohistochemical staining for the hyaluronic acid receptor CD44 revealed that MLA-type picosecond laser treatment upregulated CD44 expression in the basilar epidermis and dermal fibroblasts. Conclusions We suggest that the hyaluronic acid-rich environment associated with CPMHA treatment may enhance MLA-type picosecond-domain laser-induced tissue reactions in the epidermis and upper dermis.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
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