Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity
- Authors
- Kim, Sujin; Kim, Wonki; Kim, Do-Hee; Jang, Jeong-Hoon; Kim, Su-Jung; Park, Sin-Aye; Hahn, Hyunggu; Han, Byung Woo; Na, Hye-Kyung; Chun, Kyung-Soo; Choi, Bu Young; Surh, Young-Joon
- Issue Date
- 15-Aug-2020
- Publisher
- Academic Press
- Keywords
- Resveratrol; PIM-1; Cancer chemoprevention; Gastric cancer
- Citation
- Archives of Biochemistry and Biophysics, v.689
- Journal Title
- Archives of Biochemistry and Biophysics
- Volume
- 689
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2546
- DOI
- 10.1016/j.abb.2020.108413
- ISSN
- 0003-9861
1096-0384
- Abstract
- The proviral integration site for Moloney murine leukemia virus (PIM) family of serine/threonine-specific kinases consist of three isoforms, that regulate proliferation, apoptosis, metabolism, invasion, and metastasis of cancer cells. Among these, abnormally elevated kinase activity of PIM-1 contributes to the progression of gastric cancer and predicts poor prognosis and a low survival rate in gastric cancer patients. In the present study, we found that resveratrol, one of the representative chemopreventive and anticarcinogenic phytochemicals, directly binds to PIM-1 and thereby inhibits its catalytic activity in human gastric cancer SNU-601 cells. This resulted in suppression of phosphorylation of the proapoptotic Bad, a known substrate of PIM-1. Resveratrol, by inactivating PIM-1, also inhibited anchorage-independent growth and proliferation of SNU-601 cells. To understand the molecular interaction between resveratrol and PIM-1, we conducted docking simulation and found that resveratrol directly binds to the PIM-1 at the ATP-binding pocket. In conclusion, the proapototic and anti-proliferative effects of resveratrol in gastric cancer cells are likely to be mediated through suppression of PIM-1 kinase activity, which may represent a novel mechanism underlying its chemopreventive and anticarcinogenic actions.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.