Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantation
DC Field | Value | Language |
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dc.contributor.author | Baek, Dong Won | - |
dc.contributor.author | Moon, Joon Ho | - |
dc.contributor.author | Lee, Jae Hoon | - |
dc.contributor.author | Kang, Ka-Won | - |
dc.contributor.author | Lee, Ho Sup | - |
dc.contributor.author | Eom, Hyeon-Seok | - |
dc.contributor.author | Lee, Enuyoung | - |
dc.contributor.author | Lee, Ji Hyun | - |
dc.contributor.author | Lee, Jeong-Ok | - |
dc.contributor.author | Park, Seong Kyu | - |
dc.contributor.author | Kim, Seok Jin | - |
dc.contributor.author | Yoo, Keon Hee | - |
dc.contributor.author | Yoon, Sung-Soo | - |
dc.contributor.author | Koh, Youngil | - |
dc.contributor.author | Kang, Hyoung Jin | - |
dc.contributor.author | Won, Jong-Ho | - |
dc.contributor.author | Lyu, Chuhl Joo | - |
dc.contributor.author | Hahn, Seung Min | - |
dc.contributor.author | Lee, Jung-Hee | - |
dc.contributor.author | Park, Joon Seong | - |
dc.contributor.author | Jo, Jae-Cheol | - |
dc.contributor.author | Mun, Yeung-Chul | - |
dc.contributor.author | Yang, Deok-Hwan | - |
dc.contributor.author | Song, Ga-Young | - |
dc.contributor.author | Lim, Sung-Nam | - |
dc.contributor.author | Sohn, Sang Kyun | - |
dc.date.accessioned | 2023-12-14T06:31:20Z | - |
dc.date.available | 2023-12-14T06:31:20Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 2044-5385 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25495 | - |
dc.description.abstract | This study aimed to identify the benefits of autologous-stem cell transplantation (auto-SCT) and allogeneic-SCT (allo-SCT) in patients with aggressive T-cell lymphomas to aid in the selection of transplantation type in clinical practice. This study retrospectively analyzed data from 598 patients who underwent transplantation for T-cell lymphomas from 2010 to 2020. In total, 317 patients underwent up-front SCT as consolidation therapy. The 3-year progression-free survival (PFS) and overall survival (OS) were 68.7% and 76.1%, respectively. Patients who underwent auto-SCT had significantly better OS (p = 0.026) than those who underwent allo-SCT; however, no statistical difference in PFS was found. Transplantation was used as a salvage therapy in 188 patients who had relapsed/refractory disease. Overall, 96 (51.1%) patients underwent auto-SCT and 92 (48.9%) patients underwent allo-SCT. Auto-SCT improved long-term survival in patients with complete remission (CR). Allo-SCT demonstrated better 3-year PFS in patients with partial remission and relapsed/refractory disease status. However, >50% of patients died within 1 year of allo-SCT. As a consolidative therapy, up-front auto-SCT demonstrated a survival benefit. Auto-SCT was also effective in patients who achieved CR after salvage therapy. If the disease persists or cannot be controlled, allo-SCT may be considered with reduced intensity conditioning. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGERNATURE | - |
dc.title | Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantation | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41408-023-00868-w | - |
dc.identifier.scopusid | 2-s2.0-85163382093 | - |
dc.identifier.wosid | 001020604200003 | - |
dc.identifier.bibliographicCitation | BLOOD CANCER JOURNAL, v.13, no.1 | - |
dc.citation.title | BLOOD CANCER JOURNAL | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.subject.keywordPlus | ALLOGENEIC TRANSPLANTATION | - |
dc.subject.keywordPlus | REMISSIONS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | RELAPSE | - |
dc.subject.keywordPlus | COHORT | - |
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