Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantationopen access
- Authors
- Baek, Dong Won; Moon, Joon Ho; Lee, Jae Hoon; Kang, Ka-Won; Lee, Ho Sup; Eom, Hyeon-Seok; Lee, Enuyoung; Lee, Ji Hyun; Lee, Jeong-Ok; Park, Seong Kyu; Kim, Seok Jin; Yoo, Keon Hee; Yoon, Sung-Soo; Koh, Youngil; Kang, Hyoung Jin; Won, Jong-Ho; Lyu, Chuhl Joo; Hahn, Seung Min; Lee, Jung-Hee; Park, Joon Seong; Jo, Jae-Cheol; Mun, Yeung-Chul; Yang, Deok-Hwan; Song, Ga-Young; Lim, Sung-Nam; Sohn, Sang Kyun
- Issue Date
- Jun-2023
- Publisher
- SPRINGERNATURE
- Citation
- BLOOD CANCER JOURNAL, v.13, no.1
- Journal Title
- BLOOD CANCER JOURNAL
- Volume
- 13
- Number
- 1
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25495
- DOI
- 10.1038/s41408-023-00868-w
- ISSN
- 2044-5385
- Abstract
- This study aimed to identify the benefits of autologous-stem cell transplantation (auto-SCT) and allogeneic-SCT (allo-SCT) in patients with aggressive T-cell lymphomas to aid in the selection of transplantation type in clinical practice. This study retrospectively analyzed data from 598 patients who underwent transplantation for T-cell lymphomas from 2010 to 2020. In total, 317 patients underwent up-front SCT as consolidation therapy. The 3-year progression-free survival (PFS) and overall survival (OS) were 68.7% and 76.1%, respectively. Patients who underwent auto-SCT had significantly better OS (p = 0.026) than those who underwent allo-SCT; however, no statistical difference in PFS was found. Transplantation was used as a salvage therapy in 188 patients who had relapsed/refractory disease. Overall, 96 (51.1%) patients underwent auto-SCT and 92 (48.9%) patients underwent allo-SCT. Auto-SCT improved long-term survival in patients with complete remission (CR). Allo-SCT demonstrated better 3-year PFS in patients with partial remission and relapsed/refractory disease status. However, >50% of patients died within 1 year of allo-SCT. As a consolidative therapy, up-front auto-SCT demonstrated a survival benefit. Auto-SCT was also effective in patients who achieved CR after salvage therapy. If the disease persists or cannot be controlled, allo-SCT may be considered with reduced intensity conditioning.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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