High-intensity walking in midlife is associated with improved memory in physically capable older adultsopen access
- Authors
- Choe, Young Min; Suh, Guk-Hee; Lee, Boung Chul; Choi, Ihn-Geun; Kim, Hyun Soo; Kim, Jong Wan; Hwang, Jaeuk; Yi, Dahyun; Kim, Jee Wook
- Issue Date
- Aug-2023
- Publisher
- BMC
- Keywords
- Walking; Memory; Alzheimer's disease; Intensity; Midlife-initiated
- Citation
- ALZHEIMERS RESEARCH & THERAPY, v.15, no.1
- Journal Title
- ALZHEIMERS RESEARCH & THERAPY
- Volume
- 15
- Number
- 1
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/25554
- DOI
- 10.1186/s13195-023-01293-8
- ISSN
- 1758-9193
1758-9193
- Abstract
- BackgroundLittle is known about the associations of midlife- and late life-initiated walking with Alzheimer's disease (AD)-related cognitive decline in humans. We aimed to investigate whether high-intensity, prolonged, midlife-initiated walking is associated with changes in AD-related cognitive decline in physically capable older adults.MethodsWe studied 188 physically capable participants aged 65-90 years without dementia who underwent comprehensive clinical assessment, including of their walking modality (i.e., intensity, duration, midlife- or late life-onset), memory- or non-memory and total cognitive performance, and blood or nutritional biomarkers.ResultsThe walking group showed better episodic memory (B = 2.852, SE = 1.214, beta = 0.144, p = 0.020), but not non-memory cognition, than the non-walking group. High-intensity walking starting in midlife was significantly associated with better episodic memory (B = 9.360, SE = 3.314, beta = 0.446, p = 0.005) compared to the non-walking group. In contrast, there were no differences in cognition according to walking duration, regardless of the onset time. The walking group also showed a similar association with overall cognition.ConclusionsAmong physically capable older adults without dementia, walking, particularly at high intensity and starting in midlife, is associated with improved episodic memory, an AD-related cognitive domain. Further attention should be paid to the role of walking in terms of AD prevention.
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