성인 남성에서 혈청 페리틴 수치와 무증상 고요산혈증의 관계: 대학병원 건강검진센터(2020) 자료를 이용하여

Abstract

Background: Serum ferritin levels can be used as an auxiliary indicator of inflammation. In addition, gout is an inflammatory disease whose risk increases with increasing uric acid levels. This study investigated the association between ferritin levels and asymptomatic hyperuricemia. Methods: A total of 13,570 patients who underwent medical examinations at a university hospital health examination Center, Korea between January 2020 and December 2020 were enrolled. After excluding women and patients already receiving treatment for gout and chronic diseases such as hypertension, diabetes, hyperlipidemia, autoimmune diseases, and malignant tumors, the final data were collected from 2,833 patients. Results: Based on the distribution of ferritin, the subjects were divided into quartiles (25th, 50th, 75th, and 100th percentiles) and evaluated. The unadjusted odds ratios by ferritin quartiles were 1.35 (95% confidence interval [CI], 1.06–1.72), 1.69 (95% CI, 1.33–2.15), and 2.77 (95% CI, 2.19–3.50) for each quartile compared to the first quartile. The odds ratio after adjusting for confounding variables such as age, body mass index, waist circumference, exercise, alcohol consumption, and smoking status was 1.20 (95% CI, 0.93–1.55), 1.40 (95% CI, 1.09–1.79), and 2.15 (95% CI, 1.68– 2.75) for each quartile compared to the first quartile. Conclusion: Hyperuricemia was significantly associated with high serum ferritin levels in adult males.