Prognostic Value of Radiomic Analysis Using Pre- and Post-Treatment <SUP>18</SUP>F-FDG-PET/CT in Patients with Laryngeal Cancer and Hypopharyngeal Canceropen access
- Authors
- Choi, Joon Ho; Choi, Joon Young; Woo, Sang-Keun; Moon, Ji Eun; Lim, Chae Hong; Park, Soo Bin; Seo, Seongho; Ahn, Yong Chan; Ahn, Myung-Ju; Moon, Seung Hwan; Park, Jung Mi
- Issue Date
- Jan-2024
- Publisher
- MDPI
- Keywords
- prognostic value; radiomics; F-18-FDG PET/CT; laryngeal cancer; hypopharyngeal cancer
- Citation
- JOURNAL OF PERSONALIZED MEDICINE, v.14, no.1
- Journal Title
- JOURNAL OF PERSONALIZED MEDICINE
- Volume
- 14
- Number
- 1
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26040
- DOI
- 10.3390/jpm14010071
- ISSN
- 2075-4426
2075-4426
- Abstract
- Background: The prognostic value of conducting F-18-FDG PET/CT imaging has yielded different results in patients with laryngeal cancer and hypopharyngeal cancer, but these results are controversial, and there is a lack of dedicated studies on each type of cancer. This study aimed to evaluate whether combining radiomic analysis of pre- and post-treatment F-18-FDG PET/CT imaging features and clinical parameters has additional prognostic value in patients with laryngeal cancer and hypopharyngeal cancer. Methods: From 2008 to 2016, data on patients diagnosed with cancer of the larynx and hypopharynx were retrospectively collected. The patients underwent pre- and post-treatment F-18-FDG PET/CT imaging. The values of Delta Pre-Post PET were measured from the texture features. Least absolute shrinkage and selection operator (LASSO) Cox regression was used to select the most predictive features to formulate a Rad-score for both progression-free survival (PFS) and overall survival (OS). Kaplan-Meier curve analysis and Cox regression were employed to assess PFS and OS. Then, the concordance index (C-index) and calibration plot were used to evaluate the performance of the radiomics nomogram. Results: Study data were collected for a total of 91 patients. The mean follow-up period was 71.5 mo. (8.4-147.3). The Rad-score was formulated based on the texture parameters and was significantly associated with both PFS (p = 0.024) and OS (p = 0.009). When predicting PFS, only the Rad-score demonstrated a significant association (HR 2.1509, 95% CI [1.100-4.207], p = 0.025). On the other hand, age (HR 1.116, 95% CI [1.041-1.197], p = 0.002) and Rad-score (HR 33.885, 95% CI [2.891-397.175], p = 0.005) exhibited associations with OS. The Rad-score value showed good discrimination when it was combined with clinical parameters in both PFS (C-index 0.802-0.889) and OS (C-index 0.860-0.958). The calibration plots also showed a good agreement between the observed and predicted survival probabilities. Conclusions: Combining clinical parameters with radiomics analysis of pre- and post-treatment F-18-FDG PET/CT parameters in patients with laryngeal cancer and hypopharyngeal cancer might have additional prognostic value.
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