Floating electrode-dielectric barrier discharge-based plasma promotes skin regeneration in a full-thickness skin defect mouse model
- Authors
- Subramaniam, Mohana Devi; Bae, Joon Suk; Son, Jiwon; Anggradita, Laurensia Danis; Kim, Min-Kyu; Lee, Min Yong; Jang, Seokyoon; Choi, Kwangok; Lee, Justine C.; Nam, seung min; Hwang, Yongsung
- Issue Date
- Feb-2024
- Publisher
- SPRINGERNATURE
- Keywords
- Wound healing; Non-thermal plasma; Collagen; Inflammation; Macrophages
- Citation
- BIOMEDICAL ENGINEERING LETTERS, v.14, no.3, pp 605 - 616
- Pages
- 12
- Journal Title
- BIOMEDICAL ENGINEERING LETTERS
- Volume
- 14
- Number
- 3
- Start Page
- 605
- End Page
- 616
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26173
- DOI
- 10.1007/s13534-024-00356-5
- ISSN
- 2093-9868
2093-985X
- Abstract
- Wound healing involves a complex and dynamic interplay among various cell types, cytokines, and growth factors. Macrophages and transforming growth factor-beta 1 (TGF-beta 1) play an essential role in different phases of wound healing. Cold atmospheric plasma has a wide range of applications in the treatment of chronic wounds. Hence, we aimed to investigate the safety and efficacy of a custom-made plasma device in a full-thickness skin defect mouse model. Here, we investigated the wound tissue on days 6 and 12 using histology, qPCR, and western blotting. During the inflammation phase of wound repair, macrophages play an important role in the onset and resolution of inflammation, showing decreased F4/80 on day 6 of plasma treatment and increased TGF-beta 1 levels. The plasma-treated group showed better epidermal epithelialization, dermal fibrosis, collagen maturation, and reduced inflammation than the control group. Our findings revealed that floating electrode-dielectric barrier discharge (FE-DBD)-based atmospheric-pressure plasma promoted significantly faster wound healing in the plasma-treated group than that in the control group with untreated wounds. Hence, plasma treatment accelerated wound healing processes without noticeable side effects and suppressed pro-inflammatory genes, suggesting that FE-DBD-based plasma could be a potential therapeutic option for treating various wounds.
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- Appears in
Collections - College of Medicine > Department of Plastic Surgery > 1. Journal Articles
- College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Neurology > 1. Journal Articles
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