Anti-osteoporotic effects of enzymatic hydrolysates of mackerel <i>Scomber japonicus</i> byproduct in MC3T3-E1 cells and ovariectomized rat model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Im, Seung Tae | - |
dc.contributor.author | Kim, Minji | - |
dc.contributor.author | Kim, Wook Chul | - |
dc.contributor.author | Lee, Yun-Su | - |
dc.contributor.author | Lee, Seung-Hong | - |
dc.date.accessioned | 2024-06-11T08:30:54Z | - |
dc.date.available | 2024-06-11T08:30:54Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 0919-9268 | - |
dc.identifier.issn | 1444-2906 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26283 | - |
dc.description.abstract | Recently, interest in fish byproduct-derived bioactive components as potential ingredients for treating and preventing osteoporosis is increasing. In this study, we investigated the antiosteoporotic effects of mackerel Scomber japonicus extracts in MC3T3-E1 preosteoblasts in vitro and ovariectomized rats in vivo. Scomber japonicus neutrase-assisted protein hydrolysate (SJNH) treatment enhanced alkaline phosphatase (ALP) activity and osteoprotegerin (OPG) level, and attenuated receptor activator of nuclear factor kappa B ligand (RANKL) level in MC3T3-E1 cells. In an osteoporotic animal model, ovariectomized (OVX) rats were administered SJNH (200 mg/kg/day) for 8 weeks. SJNH prevented OVX-induced bone mineral density (BMD) loss and restored bone structural compartment loss based on micro-computed tomography (CT). In addition, SJNH administration normalized bone remodeling by regulating bone regeneration and resorption-related proteins such as ALP, osteocalcin (OC), and tartrate-resistant acid phosphatase 5b (TRACP-5b) as well as calcium contents in serum. Taken together, our findings suggest that SJNH can promote antiosteoporotic effects both in vitro and in vivo. Thus, SJNH might be a potent therapeutic agent or functional food ingredient for preventing osteoporosis. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER JAPAN KK | - |
dc.title | Anti-osteoporotic effects of enzymatic hydrolysates of mackerel <i>Scomber japonicus</i> byproduct in MC3T3-E1 cells and ovariectomized rat model | - |
dc.type | Article | - |
dc.publisher.location | 일본 | - |
dc.identifier.doi | 10.1007/s12562-024-01789-8 | - |
dc.identifier.scopusid | 2-s2.0-85192240260 | - |
dc.identifier.wosid | 001215557300001 | - |
dc.identifier.bibliographicCitation | FISHERIES SCIENCE | - |
dc.citation.title | FISHERIES SCIENCE | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Fisheries | - |
dc.relation.journalWebOfScienceCategory | Fisheries | - |
dc.subject.keywordPlus | BIOACTIVE COMPOUNDS | - |
dc.subject.keywordPlus | DIETARY-PROTEIN | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | TAURINE | - |
dc.subject.keywordPlus | VALORIZATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordAuthor | Scomber japonicus byproduct | - |
dc.subject.keywordAuthor | Protein hydrolysate | - |
dc.subject.keywordAuthor | Ovariectomized rat | - |
dc.subject.keywordAuthor | Antiosteoporosis | - |
dc.subject.keywordAuthor | Functional food | - |
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