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Genomic and evolutionary characteristics of metastatic gastric cancer by routesopen access

Authors
Lee, Jae EunKim, Ki TaeShin, Su-JinCheong, Jae-HoChoi, Yoon Young
Issue Date
Sep-2023
Publisher
SPRINGERNATURE
Citation
BRITISH JOURNAL OF CANCER, v.129, no.4, pp 672 - 682
Pages
11
Journal Title
BRITISH JOURNAL OF CANCER
Volume
129
Number
4
Start Page
672
End Page
682
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26530
DOI
10.1038/s41416-023-02338-3
ISSN
0007-0920
1532-1827
Abstract
BackgroundIn gastric cancer (GC) patients, metastatic progression through the lymphatic, hematogenous, peritoneal, and ovarian routes, is the ultimate cause of death. However, the genomic and evolutionary characteristics of metastatic GC have not been widely evaluated.MethodsWhole-exome sequencing data were analyzed for 99 primary and paired metastatic gastric cancers from 15 patients who underwent gastrectomy and metastasectomy.ResultsHematogenous metastatic tumors were associated with increased chromosomal instability and de novo gain/amplification in cancer driver genes, whereas peritoneal/ovarian metastasis was linked to sustained chromosomal stability and de novo somatic mutations in driver genes. The genomic distance of the hematogenous and peritoneal metastatic tumors was found to be closer to the primary tumors than lymph node (LN) metastasis, while ovarian metastasis was closer to LN and peritoneal metastasis than the primary tumor. Two migration patterns for metastatic GCs were identified; branched and diaspora. Both molecular subtypes of the metastatic tumors, rather than the primary tumor, and their migration patterns were related to patient survival.ConclusionsGenomic characteristics of metastatic gastric cancer is distinctive by routes and associated with patients' prognosis along with genomic evolution pattenrs, indicating that both primary and metastatic gastric cancers require genomic evaluation.
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