Effects of Treating Subclinical Rejection 2 Weeks After Kidney Transplantation, as Determined by Analyzing 1-Year Histologic Outcomesopen access
- Authors
- Lee, Okjo; Kim, Min Jung; Lee, Jung Eun; Kwon, Ghee Young; Hwang, Na Young; Kim, Kyunga; Park, Jae Berm; Lee, Kyo Won
- Issue Date
- May-2023
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- TRANSPLANTATION PROCEEDINGS, v.55, no.4, pp 769 - 776
- Pages
- 8
- Journal Title
- TRANSPLANTATION PROCEEDINGS
- Volume
- 55
- Number
- 4
- Start Page
- 769
- End Page
- 776
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/26545
- DOI
- 10.1016/j.transproceed.2023.03.005
- ISSN
- 0041-1345
1873-2623
- Abstract
- Subclinical rejection (SCR) is associated with chronic allograft nephropathy. Therefore, early detection and treatment of SCR through a protocol biopsy (PB) can reduce the incidence of pathologic changes. This study evaluates the impact of early detection and treatment of SCR using a routine PB 2 weeks after kidney transplantation (KT) by examining histologic outcomes 1 year later. We reviewed 624 KT recipients at the Samsung Medical Center between August 2012 and December 2018. Protocol biopsy was planned 2 weeks and 1 year after transplantation. We compared the histologic changes between the 2 biopsies. After a propensity score matching analysis, we divided the patients into 2 groups: the proven normal group (n = 256) and the rejection group (n = 96) at the PB taken 2 weeks post-transplant. The rejection group showed no significant difference from the normal group in the flow of graft function or the Kaplan-Meier curve for graft survival. In the histologic outcomes, the pathologic differences between the groups significantly improved between the 2 time points. Treating SCR through a PB 2 weeks after KT can contribute to the maintenance of graft function and improve histologic changes 1 year after KT.
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Collections - College of Medicine > Department of General Surgery > 1. Journal Articles
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