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NOX4 Deficiency Exacerbates the Impairment of Cystatin C-Dependent Hippocampal Neurogenesis by a Chronic High Fat Dietopen access

Authors
Jiranugrom, PiyanartYoo, Ik DongPark, Min WooRyu, Ji HwanMoon, Jong-SeokYi, Sun Shin
Issue Date
May-2020
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
NOX4; hippocampus; neurogenesis; Cystatin C; high fat diet
Citation
Genes, v.11, no.5
Journal Title
Genes
Volume
11
Number
5
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2853
DOI
10.3390/genes11050567
ISSN
2073-4425
Abstract
Hippocampal neurogenesis is linked with a cognitive process under a normal physiological condition including learning, memory, pattern separation, and cognitive flexibility. Hippocampal neurogenesis is altered by multiple factors such as the systemic metabolic changes. NADPH oxidase 4 (NOX4) has been implicated in the regulation of brain function. While the role of NOX4 plays in the brain, the mechanism by which NOX4 regulates hippocampal neurogenesis under metabolic stress is unclear. In this case, we show that NOX4 deficiency exacerbates the impairment of hippocampal neurogenesis by inhibiting neuronal maturation by a chronic high fat diet (HFD). NOX4 deficiency resulted in less hippocampal neurogenesis by decreasing doublecortin (DCX)-positive neuroblasts, a neuronal differentiation marker, and their branched-dendrites. Notably, NOX4 deficiency exacerbates the impairment of hippocampal neurogenesis by chronic HFD. Moreover, NOX4 deficiency had a significant reduction of Cystatin C levels, which is critical for hippocampal neurogenesis, under chronic HFD as well as normal chow (NC) diet. Furthermore, the reduction of Cystatin C levels was correlated with the impairment of hippocampal neurogenesis in NOX4 deficient and wild-type (WT) mice under chronic HFD. Our results suggest that NOX4 regulates the impairment of Cystatin C-dependent hippocampal neurogenesis under chronic HFD.
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College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
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