Effect of oligoarginine conjugation on the antiwrinkle activity and transdermal delivery of GHK peptide
DC Field | Value | Language |
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dc.contributor.author | Hur, Ga-Hee | - |
dc.contributor.author | Han, Sang-Cheol | - |
dc.contributor.author | Ryu, A-Reum | - |
dc.contributor.author | Eom, Youngsic | - |
dc.contributor.author | Kim, Jhin-Wook | - |
dc.contributor.author | Lee, Mi-Young | - |
dc.date.accessioned | 2021-08-11T08:37:56Z | - |
dc.date.available | 2021-08-11T08:37:56Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 1075-2617 | - |
dc.identifier.issn | 1099-1387 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3155 | - |
dc.description.abstract | GHK (Gly-His-Lys), a natural peptide found in human skin and plasma, has been widely used in the cosmeceutical and pharmaceutical fields. The hydrophilic GHK and GHK-Cu are limited in their abilities to penetrate deeply into skin; because of this, various strategies for their skin delivery have been developed. In this investigation, Arg(4) was conjugated with GHK to get heptapeptide, GHK-R4, and then in vitro antiwrinkle activity and transdermal delivery were compared between GHK and GHK-R4. Notably, Arg(4) conjugation accelerated the cellular penetration of GHK both in vitro and in vivo. Furthermore, higher in vitro antiwrinkle activity and collagen biosynthesis was obtained with GHK-R4 at much lower doses than with control R4-free GHK. The enhanced activity and delivery of GHK-R4 might be due to the cell penetrating ability and matrix metalloproteinase (MMP) inhibitory activity of R4 itself. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Effect of oligoarginine conjugation on the antiwrinkle activity and transdermal delivery of GHK peptide | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/psc.3234 | - |
dc.identifier.scopusid | 2-s2.0-85075724395 | - |
dc.identifier.wosid | 000499596600001 | - |
dc.identifier.bibliographicCitation | Journal of Peptide Science, v.26, no.2 | - |
dc.citation.title | Journal of Peptide Science | - |
dc.citation.volume | 26 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordPlus | CELL-PENETRATING PEPTIDES | - |
dc.subject.keywordPlus | TOPICAL DELIVERY | - |
dc.subject.keywordPlus | SKIN PENETRATION | - |
dc.subject.keywordPlus | COPPER PEPTIDE | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordAuthor | peptide | - |
dc.subject.keywordAuthor | antiwrinkle | - |
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