Effect of oligoarginine conjugation on the antiwrinkle activity and transdermal delivery of GHK peptide
- Authors
- Hur, Ga-Hee; Han, Sang-Cheol; Ryu, A-Reum; Eom, Youngsic; Kim, Jhin-Wook; Lee, Mi-Young
- Issue Date
- Feb-2020
- Publisher
- John Wiley & Sons Inc.
- Keywords
- peptide; antiwrinkle
- Citation
- Journal of Peptide Science, v.26, no.2
- Journal Title
- Journal of Peptide Science
- Volume
- 26
- Number
- 2
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3155
- DOI
- 10.1002/psc.3234
- ISSN
- 1075-2617
1099-1387
- Abstract
- GHK (Gly-His-Lys), a natural peptide found in human skin and plasma, has been widely used in the cosmeceutical and pharmaceutical fields. The hydrophilic GHK and GHK-Cu are limited in their abilities to penetrate deeply into skin; because of this, various strategies for their skin delivery have been developed. In this investigation, Arg(4) was conjugated with GHK to get heptapeptide, GHK-R4, and then in vitro antiwrinkle activity and transdermal delivery were compared between GHK and GHK-R4. Notably, Arg(4) conjugation accelerated the cellular penetration of GHK both in vitro and in vivo. Furthermore, higher in vitro antiwrinkle activity and collagen biosynthesis was obtained with GHK-R4 at much lower doses than with control R4-free GHK. The enhanced activity and delivery of GHK-R4 might be due to the cell penetrating ability and matrix metalloproteinase (MMP) inhibitory activity of R4 itself.
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Collections - College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles
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