Treatment Satisfaction with Flexible-dose Fesoterodine in Patients with Overactive Bladder who were Dissatisfied with Previous Anticholinergic Therapy: A Multicenter Single-Arm Clinical Studyopen access
- Authors
- Choi, Jin Bong; Cho, Kang Jun; Park, Won Hee; Lee, Dong Hwan; Kim, Young-Ho; Cho, In Rae; Yoon, Hana; Kim, Young Sik; Kim, Joon Chul
- Issue Date
- Jan-2020
- Publisher
- Urology and Nephrology Research Center
- Keywords
- fesoterodine; overactive bladder; patient satisfaction
- Citation
- Urology journal, v.17, no.1, pp 97 - 101
- Pages
- 5
- Journal Title
- Urology journal
- Volume
- 17
- Number
- 1
- Start Page
- 97
- End Page
- 101
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3220
- DOI
- 10.22037/uj.v0i0.4650
- ISSN
- 1735-1308
1735-546X
- Abstract
- Purpose: We investigated treatment satisfaction with flexible-dose fesoterodine in patients with overactive bladder (OAB) who were dissatisfied with previous anticholinergic therapy. Materials and Methods: The subjects were prescribed fesoterodine 4 mg for 4 weeks and fesoterodine 4 mg or 8 mg for another 8 weeks. The primary end point of this study was patients' satisfaction after 12 weeks of fesoterodine treatment on a five-point Likert scale. Secondary end points included a change in the number of daytime micturition, urgency incontinence episodes, urgency episodes, and nocturnal micturition in a -24hour period from baseline to final assessment. Results: Overall, 84 patients were assigned to the treatment group in this study and 63 patients completed the -12week treatment course. A final fesoterodine dose of 4 mg and 8 mg was used by %71.4) 45) and %28.6) 18) patients, respectively. The satisfaction and dissatisfaction rates at 12 weeks were %69.9 and %14.2, respectively. Mean changes in the daytime micturitions (4.72 +/- 9.73 vs. 2.86 +/- 7.76), urgency episodes (5.68 +/- 7.73 vs. +/- 3.71 4.09), and nocturnal micturitions (1.36 +/- 2.13 vs. 1.12 +/- 1.68) in 24 hours improved significantly with flexible-dose fesoterodine treatment (P < .05). Most adverse events were mild and none were severe. Conclusion: The flexible dose fesoterodine represents an alternative treatment modality in patients with OAB who are dissatisfied with previous anticholinergic therapy in Korea.
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