Suppressive effects of dehydrocostus lactone on the toll-like receptor signaling pathways
- Authors
- Kim, Su Yeon; Heo, Sunghye; Kim, Seung Han; Kwon, Minji; Sung, Nam Ji; Ryu, A-Reum; Lee, Mi-Young; Park, Sin-Aye; Youn, Hyung-Sun
- Issue Date
- Jan-2020
- Publisher
- Elsevier BV
- Keywords
- Dehydrocostus lactone; Toll-like receptor; MyD88; TRIF; IRF3
- Citation
- International Immunopharmacology, v.78
- Journal Title
- International Immunopharmacology
- Volume
- 78
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3242
- DOI
- 10.1016/j.intimp.2019.106075
- ISSN
- 1567-5769
1878-1705
- Abstract
- Toll-like receptors (TLRs) are a group of pattern-recognition receptors (PRRs) that are at the core of innate and adaptive immune responses. TLRs activation triggers the activation of two downstream signaling pathways, the myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent pathways. To evaluate the therapeutic potential of DHL, a natural sesquiterpene lactone derived from Inulahelenium L. and Saussurea lappa, we examined its effect on signal transduction via the TLR signaling pathways. DHL inhibited the activation of nuclear factor-kappa B (NF-kappa B) and interferon regulatory factor 3 (IRF3), the representative transcription factors involved in the inflammatory response, induced by TLR agonists, as well as the expression of cyclooxygenase-2 and interferon inducible protein-10. DHL also inhibited the activation of NF-KB and IRF3 induced by the overexpression of downstream signaling components of the TLRs signaling pathways. All results suggest that DHL might become a new therapeutic drug for a variety of inflammatory diseases.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
- College of Medical Sciences > Department of Medical Biotechnology > 1. Journal Articles
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