Enterotoxigenic Bacteroides fragilis infection exacerbates tumorigenesis in AOM/DSS mouse model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Soonjae | - |
dc.contributor.author | Lee, Chang Gun | - |
dc.contributor.author | Jo, Minjeong | - |
dc.contributor.author | Park, Chan Oh | - |
dc.contributor.author | Gwon, Sun-Yeong | - |
dc.contributor.author | Hwang, Samnoh | - |
dc.contributor.author | Yi, Hye Chin | - |
dc.contributor.author | Lee, So-Yeon | - |
dc.contributor.author | Eom, Yong-Bin | - |
dc.contributor.author | Karim, Baktiar | - |
dc.contributor.author | Rhee, Ki-Jong | - |
dc.date.accessioned | 2021-08-11T08:43:56Z | - |
dc.date.available | 2021-08-11T08:43:56Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1449-1907 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3734 | - |
dc.description.abstract | The azoxymethane (AOM)/dextran sulfate sodium (DSS) murine model is commonly used to study colitis-associated cancer. The human commensal bacterium, enterotoxigenic Bacteroides fragilis (ETBF) secretes the Bacteroides fragilis toxin (BFT) which is necessary and sufficient to cause colitis. We report that BALB/c mice infected with WT-ETBF and administered three cycles of AOM/DSS developed numerous, large-sized polyps predominantly in the colorectal region. In addition, AOM/DSS-treated BALB/c mice orally inoculated with wild-type nontoxigenic Bacteroides fragilis (WT-NTBF) overexpressing bft (rETBF) developed numerous polyps whereas mice infected with WT-NTBF overexpressing a biologically inactive bft (rNTBF) did not promote polyp formation. Unexpectedly, the combination of AOM+ETBF did not induce polyp formation whereas ETBF+DSS did induce polyp development in a subset of BALB/c mice. In conclusion, WT-ETBF promoted polyp development in AOM/DSS murine model with increased colitis in BALB/c mice. The model described herein provides an experimental platform for understanding ETBF-induced colonic tumorigenesis and studying colorectal cancer in wild-type mice. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Ivyspring International Publisher | - |
dc.title | Enterotoxigenic Bacteroides fragilis infection exacerbates tumorigenesis in AOM/DSS mouse model | - |
dc.type | Article | - |
dc.publisher.location | 호주 | - |
dc.identifier.doi | 10.7150/ijms.38371 | - |
dc.identifier.scopusid | 2-s2.0-85077549458 | - |
dc.identifier.wosid | 000508259400001 | - |
dc.identifier.bibliographicCitation | International Journal of Medical Sciences, v.17, no.2, pp 145 - 152 | - |
dc.citation.title | International Journal of Medical Sciences | - |
dc.citation.volume | 17 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 145 | - |
dc.citation.endPage | 152 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | DEXTRAN SODIUM-SULFATE | - |
dc.subject.keywordPlus | COLON CARCINOGENESIS | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | COLITIS | - |
dc.subject.keywordPlus | AZOXYMETHANE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | COMMENSAL | - |
dc.subject.keywordAuthor | ETBF | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | azoxymethane | - |
dc.subject.keywordAuthor | dextran sulfate sodium | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.