Efficacy of zerumbone against dual-species biofilms of Candida albicans and Staphylococcus aureus
DC Field | Value | Language |
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dc.contributor.author | Shin, Da-Seul | - |
dc.contributor.author | Eom, Yong-Bin | - |
dc.date.accessioned | 2021-08-11T08:44:18Z | - |
dc.date.available | 2021-08-11T08:44:18Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 0882-4010 | - |
dc.identifier.issn | 1096-1208 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3846 | - |
dc.description.abstract | Candida albicans and Staphylococcus aureus are the most common opportunistic pathogens that co-exist as mixed biofilms. Dual-species biofilms of C. albicans and S. aureus cause nosocomial medical device-related infections that are strongly resistant to antibiotics and host immune responses compared with mono-species biofilms. The purpose of this study was to describe the efficacy of zerumbone derived from Zingiber zerumbet (L.) Smith, on dual-species biofilm formation. This study examined the inhibitory effects of zerumbone on planktonic cell growth, adhesion and biofilm formation. The results demonstrated that zerumbone remarkably inhibited mono- and dual-species biofilms formed by C. albicans and S. aureus using the XTT [2,3-bis(2-smethoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide]-reduction assay. Furthermore, a significant decrease in biomass and cell density of dual-species biofilms following zerumbone treatment was confirmed using confocal laser scanning microscopy (CLSM). Therefore, our study suggests that zerumbone is a potential antimicrobial and antibiofilm agent indicated for the therapeutic management of nosocomial medical device-related infections induced by dual-species biofilms of C. albicans and S. aureus. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Efficacy of zerumbone against dual-species biofilms of Candida albicans and Staphylococcus aureus | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.micpath.2019.103768 | - |
dc.identifier.scopusid | 2-s2.0-85072863765 | - |
dc.identifier.wosid | 000502891200040 | - |
dc.identifier.bibliographicCitation | Microbial Pathogenesis, v.137 | - |
dc.citation.title | Microbial Pathogenesis | - |
dc.citation.volume | 137 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | POLYMICROBIAL BIOFILMS | - |
dc.subject.keywordPlus | FARNESOL | - |
dc.subject.keywordAuthor | Candida albicans | - |
dc.subject.keywordAuthor | Staphylococcus aureus | - |
dc.subject.keywordAuthor | Zerumbone | - |
dc.subject.keywordAuthor | Dual-species biofilm | - |
dc.subject.keywordAuthor | Antibiofilm activity | - |
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