Efficacy of zerumbone against dual-species biofilms of Candida albicans and Staphylococcus aureus
- Authors
- Shin, Da-Seul; Eom, Yong-Bin
- Issue Date
- Dec-2019
- Publisher
- Elsevier BV
- Keywords
- Candida albicans; Staphylococcus aureus; Zerumbone; Dual-species biofilm; Antibiofilm activity
- Citation
- Microbial Pathogenesis, v.137
- Journal Title
- Microbial Pathogenesis
- Volume
- 137
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3846
- DOI
- 10.1016/j.micpath.2019.103768
- ISSN
- 0882-4010
1096-1208
- Abstract
- Candida albicans and Staphylococcus aureus are the most common opportunistic pathogens that co-exist as mixed biofilms. Dual-species biofilms of C. albicans and S. aureus cause nosocomial medical device-related infections that are strongly resistant to antibiotics and host immune responses compared with mono-species biofilms. The purpose of this study was to describe the efficacy of zerumbone derived from Zingiber zerumbet (L.) Smith, on dual-species biofilm formation. This study examined the inhibitory effects of zerumbone on planktonic cell growth, adhesion and biofilm formation. The results demonstrated that zerumbone remarkably inhibited mono- and dual-species biofilms formed by C. albicans and S. aureus using the XTT [2,3-bis(2-smethoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide]-reduction assay. Furthermore, a significant decrease in biomass and cell density of dual-species biofilms following zerumbone treatment was confirmed using confocal laser scanning microscopy (CLSM). Therefore, our study suggests that zerumbone is a potential antimicrobial and antibiofilm agent indicated for the therapeutic management of nosocomial medical device-related infections induced by dual-species biofilms of C. albicans and S. aureus.
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Collections - College of Medical Sciences > Department of Biomedical Laboratory Science > 1. Journal Articles
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