Clinical outcomes of patients with a single hepa-tocellular carcinoma less than 5 cm treated with transarterial chemoembolizationopen access
- Authors
- Baek, Min Young; Yoo, Jeong-Ju; Jeong, Soung Won; Jang, Jae Young; Kim, Yong Kwon; Jeong, Shin Ok; Lee, Sae Hwan; Kim, Sang Gyune; Cha, Sang-Woo; Kim, Young Seok; Cho, Young Deok; Kim, Hong Soo; Kim, Boo Sung; Kim, Yong Jae; Park, Su Yeon
- Issue Date
- Nov-2019
- Publisher
- 대한내과학회
- Keywords
- Carcinoma; hepatocellular; Chemoembolization; Therapeutic; Survival
- Citation
- The Korean Journal of Internal Medicine, v.34, no.6, pp 1223 - 1232
- Pages
- 10
- Journal Title
- The Korean Journal of Internal Medicine
- Volume
- 34
- Number
- 6
- Start Page
- 1223
- End Page
- 1232
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4119
- DOI
- 10.3904/kjim.2018.058
- ISSN
- 1226-3303
2005-6648
- Abstract
- Background/Aims: Transarterial chemoembolization (TACE) is performed for single hepatocellular carcinoma (HCC) that are not eligible for surgery or ablation therapy. We investigated the clinical outcomes of patients with a single HCC <= 5 cm treated with TACE. Methods: This study analyzed 175 consecutive patients who underwent TACE as an initial treatment for single HCC <= 5 cm. Predictive factors for complete response (CR), recurrence after CR, and overall survival (OS) were evaluated. Results: Total 119 patients (68%) achieved CR after TACE. Tumor size < 3 cm and hepatitis B virus infection were significant predictors of CR (p < 0.05). Recurrent HCC was detected in 73 patients (61.3%) after CR. Age > 65 years and absence of liver cirrhosis were predictive factors for non-recurrence after CR (p < 0.05). The OS for all patients was 80.7 +/- 5.6 months, and the 1-, 3-, and 5-year OS rates were 88.1%, 64.8%, and 49.9%, respectively. In multivariate analysis for OS, CR (hazard ratio [HR], 0.467; 95% confidence interval [CI], 0.292 to 0.747) and Child class A (HR, 0.390; 95% CI, 0.243 to 0.626) were significant factors. The OS for the CR and Child class A group were 92 and 93.6 months, respectively, and that of the non-CR and Child B, C group were 53.3 and 50.7 months, respectively (p < 0.001). Conclusions: TACE can be a valid treatment in patients with a single HCC <= 5 cm not suitable for curative treatment, especially in patients with Child class A and CR after TACE.
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Collections - College of Medicine > Department of Radiology > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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