Evaluation of prognostic factor and nature of acute esophageal necrosis Restropective multicenter studyopen access
- Authors
- Kim, Sun Moon; Song, Kyung Ho; Kang, Sun Hyung; Moon, Hee Seok; Sung, Jae Kyu; Kim, Sae Hee; Kim, Ki Bae; Lee, Seung Woo; Cho, Young Sin; Bang, Ki Bae
- Issue Date
- Oct-2019
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Keywords
- acute esophageal necrosis; prognostic factor; white esophagus
- Citation
- Medicine, v.98, no.41
- Journal Title
- Medicine
- Volume
- 98
- Number
- 41
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4174
- DOI
- 10.1097/MD.0000000000017511
- ISSN
- 0025-7974
1536-5964
- Abstract
- Acute esophageal necrosis (AEN) is a serious disease which can causes gastrointestinal bleeding and death. Although black color change is not essential factor of organ necrosis, AEN is also known as "black esophagus." Because of its rarity, there are limited studies regarding risk factors of mortality and recurrence. Thus, we conducted a multicenter retrospective study in order to evaluate the clinical characteristics of AEN. Method Clinical datum of AEN patients from 7 tertiary hospitals located in Daejeon-Choongcheong province were evaluated based on medical records. Our primary endpoint was risk factors for mortality and the secondary endpoint was risk factors for recurrence and clarifying whether "black esophagus" is a right terminology. Fourty one patients were enrolled. Thirty six patients were male, mean age was 69.5 years. Nine patients had died, and 4 patients showed recurrence. Sepsis and white color change in endoscopy were related to high mortality (Chi-Squared test, P<.05). Old age, high pulse rate, low hemoglobin, and low albumin were also related to high mortality. Unexpectedly, heavy drinking showed favorable a mortality. Septic condition and high pulse rate showed poor mortality in logistic regression test (P<.05). Coexisting duodenal ulcer was related to recurrence (Chi-Squared test, P<.05). There was no difference in the underlying condition except patients with a coexisting cancer and white-form displayed lower hemoglobin level. Conclusion: Our results imply that white color change, septic condition, high pulse rate, and low hemoglobin & albumin are poor prognostic factors in AEN. Further evaluation may help clarify the findings of our study.
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