The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies
DC Field | Value | Language |
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dc.contributor.author | Liu, Chenxing | - |
dc.contributor.author | Kanazawa, Tetsufumi | - |
dc.contributor.author | Tian, Ye | - |
dc.contributor.author | Saini, Suriati Mohamed | - |
dc.contributor.author | Mancuso, Serafino | - |
dc.contributor.author | Mostaid, Md Shaki | - |
dc.contributor.author | Takahashi, Atsushi | - |
dc.contributor.author | Zhang, Dai | - |
dc.contributor.author | Zhang, Fuquan | - |
dc.contributor.author | Yu, Hao | - |
dc.contributor.author | Shin, Hyoung Doo | - |
dc.contributor.author | Cheong, Hyun Sub | - |
dc.contributor.author | Ikeda, Masashi | - |
dc.contributor.author | Kubo, Michiaki | - |
dc.contributor.author | Iwata, Nakao | - |
dc.contributor.author | Woo, Sung-Il | - |
dc.contributor.author | Yue, Weihua | - |
dc.contributor.author | Kamatani, Yoichiro | - |
dc.contributor.author | Shi, Yongyong | - |
dc.contributor.author | Li, Zhiqiang | - |
dc.contributor.author | Everall, Ian | - |
dc.contributor.author | Pantelis, Christos | - |
dc.contributor.author | Bousman, Chad | - |
dc.date.accessioned | 2021-08-11T09:24:40Z | - |
dc.date.available | 2021-08-11T09:24:40Z | - |
dc.date.issued | 2019-08-27 | - |
dc.identifier.issn | 2158-3188 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4299 | - |
dc.description.abstract | Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies' findings has not been undertaken since the decommissioning of the schizophrenia gene (SzGene) database in 2011. As such, we systematically identified and carried out random-effects meta-analyses for all polymorphisms with four or more independent studies in schizophrenia along with a series of expanded meta-analyses incorporating published and unpublished genome-wide association (GWA) study data. Based on 550 meta-analyses, 11 SNPs in eight linkage disequilibrium (LD) independent loci showed Bonferroni-significant associations with schizophrenia. Expanded meta-analyses identified an additional 10 SNPs, for a total of 21 Bonferroni-significant SNPs in 14 LD-independent loci. Three of these loci (MTHFR, DAOA, ARVCF) had never been implicated by a schizophrenia GWA study. In sum, the present study has provided a comprehensive summary of the current schizophrenia genetics knowledgebase and has made available all the collected data as a resource for the research community. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41398-019-0532-4 | - |
dc.identifier.wosid | 000483954200001 | - |
dc.identifier.bibliographicCitation | Translational Psychiatry, v.9 | - |
dc.citation.title | Translational Psychiatry | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | METAANALYSES | - |
dc.subject.keywordAuthor | Schizophrenia | - |
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