The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studiesopen access
- Authors
- Liu, Chenxing; Kanazawa, Tetsufumi; Tian, Ye; Saini, Suriati Mohamed; Mancuso, Serafino; Mostaid, Md Shaki; Takahashi, Atsushi; Zhang, Dai; Zhang, Fuquan; Yu, Hao; Shin, Hyoung Doo; Cheong, Hyun Sub; Ikeda, Masashi; Kubo, Michiaki; Iwata, Nakao; Woo, Sung-Il; Yue, Weihua; Kamatani, Yoichiro; Shi, Yongyong; Li, Zhiqiang; Everall, Ian; Pantelis, Christos; Bousman, Chad
- Issue Date
- 27-Aug-2019
- Publisher
- Nature Publishing Group
- Keywords
- Schizophrenia
- Citation
- Translational Psychiatry, v.9
- Journal Title
- Translational Psychiatry
- Volume
- 9
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4299
- DOI
- 10.1038/s41398-019-0532-4
- ISSN
- 2158-3188
- Abstract
- Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies' findings has not been undertaken since the decommissioning of the schizophrenia gene (SzGene) database in 2011. As such, we systematically identified and carried out random-effects meta-analyses for all polymorphisms with four or more independent studies in schizophrenia along with a series of expanded meta-analyses incorporating published and unpublished genome-wide association (GWA) study data. Based on 550 meta-analyses, 11 SNPs in eight linkage disequilibrium (LD) independent loci showed Bonferroni-significant associations with schizophrenia. Expanded meta-analyses identified an additional 10 SNPs, for a total of 21 Bonferroni-significant SNPs in 14 LD-independent loci. Three of these loci (MTHFR, DAOA, ARVCF) had never been implicated by a schizophrenia GWA study. In sum, the present study has provided a comprehensive summary of the current schizophrenia genetics knowledgebase and has made available all the collected data as a resource for the research community.
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