Assessment of phase-lag entropy, a new measure of electroencephalographic signals, for propofol-induced sedationopen access
- Authors
- Jun, Mi Roung; Yoo, Jae Hwa; Park, Sun Young; Na, Sojin; Kwon, Hyerim; Nho, Jae-Hwi; Kim, Soon Im
- Issue Date
- Aug-2019
- Publisher
- 대한마취통증의학회
- Keywords
- Consciousness monitor; Electroencephalography; Propofol; Sedation
- Citation
- Korean Journal of Anesthesiology, v.72, no.4, pp 351 - 356
- Pages
- 6
- Journal Title
- Korean Journal of Anesthesiology
- Volume
- 72
- Number
- 4
- Start Page
- 351
- End Page
- 356
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4351
- DOI
- 10.4097/kja.d.19.00019
- ISSN
- 2005-6419
2005-7563
- Abstract
- Background: Phase-lag entropy (PLE) was recently described as a measurement of temporal pattern diversity in the phase relationship between two electroencephalographic signals from prefrontal and frontal montages. This study was performed to evaluate the performance of PLE for assessing the depth of sedation. Methods: Thirty adult patients undergoing upper limb surgery with a brachial plexus block were administered propofol by target-controlled infusion. The depth of sedation was assessed using the Observer's Assessment of Alertness/Sedation (OAA/S) scale. The effect-site concentration (Ce) of propofol was initially started at 0.5 mu g/ml and was increased in increments of 0.2 mu g/ml until an OAA/S score of 1 was reached. Three minutes after the target Ce was reached, the PLE, bispectral index (BIS), and level of sedation were assessed. Correlations between the OAA/S score and PLE or BIS were determined. The prediction probabilities (P-k) of PLE and BIS were also analyzed. Results: The PLE values were closely correlated with the OAA/S scores (Spearman's Rho = 0.755; P < 0.001) to an extent comparable with the correlation between the BIS and OAA/S score (Spearman's Rho = 0.788; P < 0.001). The P-k values of PLE and BIS were 0.731 and 0.718, respectively. Conclusions: PLE is a new and reliable consciousness monitoring system for assessing the depth of sedation induced by propofol, which is comparable with the BIS.
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Collections - College of Medicine > Department of Orthopedic Surgery > 1. Journal Articles
- College of Medicine > Department of Anesthesiology > 1. Journal Articles
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