Prognostic significance of IFITM1 expression and correlation with microvessel density and epithelial-mesenchymal transition signature in lung adenocarcinoma
- Authors
- Koh, Young Wha; Han, Jae-Ho; Jeong, Dongjun; Kim, Chang-Jin
- Issue Date
- Jul-2019
- Publisher
- Elsevier BV
- Keywords
- Lung adenocarcinoma; Interferon-induced transmembrane protein 1; Microvessel; Density; Epithelial-mesenchymal transition; Prognosis
- Citation
- Pathology Research and Practice, v.215, no.7
- Journal Title
- Pathology Research and Practice
- Volume
- 215
- Number
- 7
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4429
- DOI
- 10.1016/j.prp.2019.152444
- ISSN
- 0344-0338
- Abstract
- We evaluated the relationship between interferon-induced transmembrane protein 1 (IFITM1) expression, epithelial-mesenchymal transition (EMT) signature and angiogenesis in lung adenocarcinoma. Additionally, we examined prognostic significance of IFITM1 according to pTNM stage to confirm that IFITM1 can serve as a complement to the pTNM stage. A total of 141 lung adenocarcinoma specimens were evaluated retrospectively by immunohistochemical staining for IFITM1, EMT markers (e-cadherin, beta-catenin, and vimentin), and CD31 to measure microvessel density. IFITM1 was expressed in 46.8% of the specimens. IFITM1 expression was significantly correlated with increased microvessel density (P = 0.048). However, IFITM1 expression was not associated with three EMT markers. In a multivariate analysis, IFITM1 was an independent prognostic factor for overall survival in a multivariate analysis (hazard ratio: 2.59, P = 0.01). Online database with data from 720 lung adenocarcinoma patients also revealed a negative prognostic significance of IFITM1 (P < 0.001). Furthermore, high IFITM1 expression was significantly correlated with decreased OS rates in each pTNM stage. IFITM1 is significantly correlated with angiogenesis and it may be used as a useful additional prognostic marker to aid pTNM classification.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
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