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Anti-melanogenesis activity of Ecklonia cava extract cultured in tanks with magma seawater of Jeju Island

Authors
Ding, YulingKim, So HuiLee, Jeong JunHong, Jin TaeKim, Eun-AKang, Do-HyungHeo, Soo-TinLee, Seung-Hong
Issue Date
Jun-2019
Publisher
한국조류학회I
Keywords
anti-melanogenesis activity; cultivation; Ecklonia cava; Jeju magma seawater; polyphenolic content
Citation
ALGAE, v.34, no.2, pp 177 - 185
Pages
9
Journal Title
ALGAE
Volume
34
Number
2
Start Page
177
End Page
185
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4497
DOI
10.4490/algae.2019.34.4.30
ISSN
1226-2617
2093-0860
Abstract
Ecklonia cava is popular in Korea as a marine functional materials. E. cava is generally collected and used on the coast of Jeju Island. however, the continuous use of collected natural E cava may be limited because difficult to secure throughout the year and may be exposed to environmental pollution. Jeju magma seawater (MSW) was known to be significant advantages such as safety, cleanness, stability, and functional improvement. Attempts have been reported on application of MSW to the culturing of macro- and microalgae and showed improved results. Thus, the objective of the present study was to explore the anti-melanogenesis activity of brown seaweed E. cava (E. cava cultured with MSW [MSWE]) extract cultured in tanks with MSW of Jeju Island to evaluate the possibility of cosmeceutical industrial application. MSWE extract showed the higher polyphenolic and dieckol contents than natural E. cava (NE) extract. Anti-melanogenesis activity of MSWE extract and NE extract are tested and compared using tyrosinase and dihydroxyphenylalanine (DOPA) oxidation inhibition assay. MSWE extracts evidenced more effective tyrosinase and DOPA oxidation inhibition activity than that of the NE extracts and the commercial whitening agent, arbutin. MSWE extracts also markedly inhibited melanin synthesis and decreased the expression of melanogenesis-related protein in alpha-melanocyte stimulating hormone-stimulated B16F10 melanoma cells without cytotoxicity. These results suggest that MSW cultivation process would be more effective in releasing bioactive compounds with whitening effect from seaweed such as E. cava at an industrial scale.
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