Visceral adipose tissue volume and CT-attenuation as prognostic factors in patients with head and neck cancer
- Authors
- Lee, Jeong Won; Ban, Myung Jin; Park, Jae Hong; Lee, Sang Mi
- Issue Date
- Jun-2019
- Publisher
- John Wiley & Sons Inc.
- Keywords
- adipose tissue; fluorodeoxyglucose F18; head and neck cancer; positron emission tomography; prognosis
- Citation
- Head and Neck, v.41, no.6, pp 1605 - 1614
- Pages
- 10
- Journal Title
- Head and Neck
- Volume
- 41
- Number
- 6
- Start Page
- 1605
- End Page
- 1614
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4506
- DOI
- 10.1002/hed.25605
- ISSN
- 1043-3074
1097-0347
- Abstract
- Background The aim of this study was to evaluate the relationship of the characteristics of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) to the disease progression-free survival and distant failure-free survival of head and neck squamous cell carcinoma (HNSCC). Methods We enrolled 152 HNSCC patients who underwent staging F-18-fluorodeoxyglucose (FDG) positron emission tomography/CT (PET/CT). Maximum FDG uptake (standardized uptake value [SUV]) and total lesion glycolysis (TLG) of the primary tumor and volume, CT-attenuation (Hounsfield units [HU]), and FDG uptake of SAT and VAT were measured. Survival analysis using Cox proportional hazard modeling was performed to assess the relationship between the adipose tissue parameters of PET/CT and survival. Results Patients with low VAT volume and high VAT HU had significantly worse progression-free survival and distant failure-free survival than those with high VAT volume and low VAT HU. On multivariate analysis, the volume and HU of VAT were significantly correlated with disease progression-free survival and distant failure-free survival after adjusting for age, sex, body mass index, TNM stage, serum C-reactive protein, maximum SUV, and TLG. Conclusion The volume and CT-attenuation of VAT were significantly correlated with disease progression-free survival and distant failure-free survival in patients with HNSCC.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Radiology > 1. Journal Articles
- College of Medicine > Department of Otorhinolaryngology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4506)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.