Association between Restless Legs Syndrome Symptoms and Self-Reported Hypertension: a Nationwide Questionnaire Study in Koreaopen access
- Authors
- Sunwoo, Jun-Sang; Kim, Won-Joo; Chu, Min Kyung; Yang, Kwang Ik
- Issue Date
- 29-Apr-2019
- Publisher
- 대한의학회
- Keywords
- Restless Legs Syndrome; Willis-Ekbom Disease; Hypertension; Prevalence
- Citation
- Journal of Korean Medical Science, v.34, no.16
- Journal Title
- Journal of Korean Medical Science
- Volume
- 34
- Number
- 16
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4578
- DOI
- 10.3346/jkms.2019.34.e130
- ISSN
- 1011-8934
1598-6357
- Abstract
- Background: The association between restless legs syndrome (RLS) and hypertension remains controversial. We investigated the relationship between RLS and hypertension in a nationwide sample of the Korean adult population. Methods: This was a cross-sectional questionnaire-based study including 2,740 adults aged 19 years or more. Subjects who met the four essential International RLS Study Group criteria and reported symptoms occurring at least once a week were defined as the RLS group. The presence of hypertension was defined as a self-reported history of physician-diagnosed hypertension. We conducted multiple logistic regression analysis to determine the independent association between RLS symptoms and self-reported hypertension after adjusting for potential confounding factors. Results: Among the 2,740 subjects, 68 (2.5%; 95% confidence interval [CI], 1.9%-3.1%) were found to have RLS with a symptom frequency of at least once a week. The prevalence of self-reported hypertension was 30.9% (95% CI, 20.5%-42.0%) in the RLS group, which was significantly higher than that in controls (12.4%; 95% CI, 11.2%-13.6%; P < 0.001). Multiple logistic regression analysis showed that the adjusted odds ratio for self-reported hypertension in the RLS group was 2.10 (95% CI, 1.12-3.93) compared to controls. In addition to RLS symptoms, old age, being overweight, low education level, diabetes mellitus, and short sleep duration were significantly associated with self-reported hypertension. Conclusion: RLS symptoms occurring at least once a week is independently associated with a higher prevalence of self-reported hypertension in the adult Korean population. Further research will confirm the clinical implication of the present results and the causal relationship between RLS and hypertension.
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Collections - College of Medicine > Department of Neurology > 1. Journal Articles
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