Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea
DC Field | Value | Language |
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dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Park, Kyung-Hwa | - |
dc.contributor.author | Choi, Hee Jung | - |
dc.contributor.author | Kim, Kye-Hyung | - |
dc.contributor.author | Lee, Shinwon | - |
dc.contributor.author | Hwang, Jeong-Hwan | - |
dc.contributor.author | Choo, Eun Ju | - |
dc.contributor.author | Park, Yoonseon | - |
dc.contributor.author | Lee, Eun Jung | - |
dc.contributor.author | Kim, Young Keun | - |
dc.contributor.author | Jeon, Min Hyok | - |
dc.contributor.author | Moon, Chisook | - |
dc.contributor.author | Hwang, Joo-Hee | - |
dc.contributor.author | Park, Jeong Su | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Bang, Ji Hwan | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.date.accessioned | 2021-08-11T09:44:13Z | - |
dc.date.available | 2021-08-11T09:44:13Z | - |
dc.date.issued | 2019-04-01 | - |
dc.identifier.issn | 1076-6294 | - |
dc.identifier.issn | 1931-8448 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4590 | - |
dc.description.abstract | Aim: Panton-Valentine leukocidin (PVL) is a virulent cytotoxin and an indicator of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection. In this study, we evaluated the prevalence and clinical and molecular characteristics of PVL-positive invasive S. aureus (ISA) infections in Korea. Results: A collection of 1,962 nonduplicate clinical isolates were screened for multilocus sequence typing, staphylococcal cassette chromosome mec (SCCmec), accessory gene regulator typing, major toxins, and antimicrobial susceptibility. Twenty-eight (1.4%) PVL-positive S. aureus samples were found; of them 19 (67.9%) were MRSA (8 CA and 11 healthcare-associated infections). Seventeen patients (60.7%) were men (median age: 63 years; range: 13-93 years) and 12 patients (42.9%) had no underlying comorbidities. The most common infections were skin and skin structure infection (SSSI) and pneumonia. The 30-day mortality rate was 37.0%. The most common PVL-positive MRSA clones were ST8-SCCmec IVa and ST30-SCCmec IVc along with their single-locus variants. Antimicrobial susceptibility and toxin-gene profile differed according to the clone. Conclusions: ISA infections caused by PVL-positive strains are rare in Korea, with the two most common infections being SSSI and pneumonia. Our findings indicated that several PVL-positive MRSA clones, predominantly ST8-SCCmecIVa and ST30-SCCmecIVc, were circulating and causing sporadic cases of ISA infections in the community and hospital settings. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Mary Ann Liebert Inc. | - |
dc.title | Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1089/mdr.2018.0238 | - |
dc.identifier.scopusid | 2-s2.0-85064073300 | - |
dc.identifier.wosid | 000448781800001 | - |
dc.identifier.bibliographicCitation | Microbial Drug Resistance, v.25, no.3, pp 450 - 456 | - |
dc.citation.title | Microbial Drug Resistance | - |
dc.citation.volume | 25 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 450 | - |
dc.citation.endPage | 456 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | METHICILLIN-RESISTANT | - |
dc.subject.keywordPlus | USA300 CLONE | - |
dc.subject.keywordPlus | COMMUNITY | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | ELEMENT | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordAuthor | Staphylococcus aureus | - |
dc.subject.keywordAuthor | Panton-Valentine leukocidin | - |
dc.subject.keywordAuthor | molecular epidemiology | - |
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