Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea
- Authors
- Song, Kyoung-Ho; Kim, Eu Suk; Park, Kyung-Hwa; Choi, Hee Jung; Kim, Kye-Hyung; Lee, Shinwon; Hwang, Jeong-Hwan; Choo, Eun Ju; Park, Yoonseon; Lee, Eun Jung; Kim, Young Keun; Jeon, Min Hyok; Moon, Chisook; Hwang, Joo-Hee; Park, Jeong Su; Park, Kyoung Un; Choe, Pyoeng Gyun; Bang, Ji Hwan; Oh, Myoung-don; Kim, Hong Bin
- Issue Date
- 1-Apr-2019
- Publisher
- Mary Ann Liebert Inc.
- Keywords
- Staphylococcus aureus; Panton-Valentine leukocidin; molecular epidemiology
- Citation
- Microbial Drug Resistance, v.25, no.3, pp 450 - 456
- Pages
- 7
- Journal Title
- Microbial Drug Resistance
- Volume
- 25
- Number
- 3
- Start Page
- 450
- End Page
- 456
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4590
- DOI
- 10.1089/mdr.2018.0238
- ISSN
- 1076-6294
1931-8448
- Abstract
- Aim: Panton-Valentine leukocidin (PVL) is a virulent cytotoxin and an indicator of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection. In this study, we evaluated the prevalence and clinical and molecular characteristics of PVL-positive invasive S. aureus (ISA) infections in Korea. Results: A collection of 1,962 nonduplicate clinical isolates were screened for multilocus sequence typing, staphylococcal cassette chromosome mec (SCCmec), accessory gene regulator typing, major toxins, and antimicrobial susceptibility. Twenty-eight (1.4%) PVL-positive S. aureus samples were found; of them 19 (67.9%) were MRSA (8 CA and 11 healthcare-associated infections). Seventeen patients (60.7%) were men (median age: 63 years; range: 13-93 years) and 12 patients (42.9%) had no underlying comorbidities. The most common infections were skin and skin structure infection (SSSI) and pneumonia. The 30-day mortality rate was 37.0%. The most common PVL-positive MRSA clones were ST8-SCCmec IVa and ST30-SCCmec IVc along with their single-locus variants. Antimicrobial susceptibility and toxin-gene profile differed according to the clone. Conclusions: ISA infections caused by PVL-positive strains are rare in Korea, with the two most common infections being SSSI and pneumonia. Our findings indicated that several PVL-positive MRSA clones, predominantly ST8-SCCmecIVa and ST30-SCCmecIVc, were circulating and causing sporadic cases of ISA infections in the community and hospital settings.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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