Detailed Information

Cited 0 time in webofscience Cited 6 time in scopus
Metadata Downloads

Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea

Authors
Song, Kyoung-HoKim, Eu SukPark, Kyung-HwaChoi, Hee JungKim, Kye-HyungLee, ShinwonHwang, Jeong-HwanChoo, Eun JuPark, YoonseonLee, Eun JungKim, Young KeunJeon, Min HyokMoon, ChisookHwang, Joo-HeePark, Jeong SuPark, Kyoung UnChoe, Pyoeng GyunBang, Ji HwanOh, Myoung-donKim, Hong Bin
Issue Date
1-Apr-2019
Publisher
Mary Ann Liebert Inc.
Keywords
Staphylococcus aureus; Panton-Valentine leukocidin; molecular epidemiology
Citation
Microbial Drug Resistance, v.25, no.3, pp 450 - 456
Pages
7
Journal Title
Microbial Drug Resistance
Volume
25
Number
3
Start Page
450
End Page
456
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4590
DOI
10.1089/mdr.2018.0238
ISSN
1076-6294
1931-8448
Abstract
Aim: Panton-Valentine leukocidin (PVL) is a virulent cytotoxin and an indicator of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection. In this study, we evaluated the prevalence and clinical and molecular characteristics of PVL-positive invasive S. aureus (ISA) infections in Korea. Results: A collection of 1,962 nonduplicate clinical isolates were screened for multilocus sequence typing, staphylococcal cassette chromosome mec (SCCmec), accessory gene regulator typing, major toxins, and antimicrobial susceptibility. Twenty-eight (1.4%) PVL-positive S. aureus samples were found; of them 19 (67.9%) were MRSA (8 CA and 11 healthcare-associated infections). Seventeen patients (60.7%) were men (median age: 63 years; range: 13-93 years) and 12 patients (42.9%) had no underlying comorbidities. The most common infections were skin and skin structure infection (SSSI) and pneumonia. The 30-day mortality rate was 37.0%. The most common PVL-positive MRSA clones were ST8-SCCmec IVa and ST30-SCCmec IVc along with their single-locus variants. Antimicrobial susceptibility and toxin-gene profile differed according to the clone. Conclusions: ISA infections caused by PVL-positive strains are rare in Korea, with the two most common infections being SSSI and pneumonia. Our findings indicated that several PVL-positive MRSA clones, predominantly ST8-SCCmecIVa and ST30-SCCmecIVc, were circulating and causing sporadic cases of ISA infections in the community and hospital settings.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Internal Medicine > 1. Journal Articles
College of Medicine > Department of Internal Medicine > 1. Journal Articles
College of Medicine > Department of Internal Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher CHOO, EUN JU photo

CHOO, EUN JU
College of Medicine (Department of Internal Medicine)
Read more

Altmetrics

Total Views & Downloads

BROWSE