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Glutathione transferase modulates acute ethanol-induced sedation in Drosophila neurones

Authors
Choi, H. -J.Cha, S. J.Kim, K.
Issue Date
Apr-2019
Publisher
Blackwell Publishing Inc.
Keywords
alcohol; ethanol sedation; glutathione transferase omega; neurone; Drosophila
Citation
Insect Molecular Biology, v.28, no.2, pp 246 - 252
Pages
7
Journal Title
Insect Molecular Biology
Volume
28
Number
2
Start Page
246
End Page
252
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4635
DOI
10.1111/imb.12547
ISSN
0962-1075
1365-2583
Abstract
Heavy alcohol consumption leads to neuropathological damage and alcohol use disorder, which affects the health of people and results in a cost burden. However, the genes modulating sensitivity to ethanol remain largely unknown. Here, we identified a novel gene, Drosophila glutathione transferase omega 1 (GstO1), which plays a critical role in regulating sensitivity to ethanol sedation. GstO1 mutant flies showed highly increased ethanol sensitivity. Furthermore, the expression level of GstO1 regulates the behavioural response to ethanol, because decreasing and increasing GstO1 affects sedation sensitivity in a contrasting manner. In addition, the RNA interference-mediated knockdown of GstO1 expression reveals that GstO1 mediates sensitivity to ethanol sedation in neurones, including dopaminergic and serotonergic neurones. Altogether, our findings provide the first evidence for the involvement of glutathione transferase in the response to alcohol in Drosophila and provide a novel mechanistic insight into the toxicity and sensitivity of ethanol exposure.
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