Association of glucagon-to-insulin ratio and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus
DC Field | Value | Language |
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dc.contributor.author | Moh, Myint Aung Moh | - |
dc.contributor.author | Jung, Chan-Hee | - |
dc.contributor.author | Lee, Bora | - |
dc.contributor.author | Choi, Dughyun | - |
dc.contributor.author | Kim, Bo-Yeon | - |
dc.contributor.author | Kim, Chul-Hee | - |
dc.contributor.author | Kang, Sung-Koo | - |
dc.contributor.author | Mok, Ji-Oh | - |
dc.date.accessioned | 2021-08-11T10:23:30Z | - |
dc.date.available | 2021-08-11T10:23:30Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 1479-1641 | - |
dc.identifier.issn | 1752-8984 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4667 | - |
dc.description.abstract | Objective: The aim of this study is to investigate the association between glucagon-to-insulin ratio and the presence of nonalcoholic fatty liver disease on ultrasonography in participants with type 2 diabetes mellitus. Research design and methods: This cross-sectional study was performed with data obtained from 172 participants with type 2 diabetes mellitus admitted to a University hospital of Korea. Participants were assessed for serum fasting and postprandial serum glucagon-to-insulin ratio and divided into tertiles. Nonalcoholic fatty liver disease was defined as ultrasonographically detected fatty liver. Results: Prevalence of nonalcoholic fatty liver disease was significantly decreased across tertile of fasting and postprandial glucagon-to-insulin ratio (p = 0.009 for trend, p = 0.001 for trend, respectively). Lower glucagon-to-insulin ratio was significantly associated with the presence of nonalcoholic fatty liver disease even after adjustment for potential confounding variables [fasting glucagon-to-insulin ratio: odds ratio (95% confidence interval), 2.68 (1.08-6.86)], postprandial glucagon-to-insulin ratio: [2.72 (1.03-7.35)]. The participants in the lowest tertile of fasting glucagon-to-insulin ratio had higher body mass index, visceral fat thickness, subcutaneous fat thickness, homeostasis model assessment-insulin resistance and shorter duration of diabetes mellitus. Conclusion: This study suggests that lower glucagon relative insulin may be independently associated with nonalcoholic fatty liver disease in participants with type 2 diabetes. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE Publications | - |
dc.title | Association of glucagon-to-insulin ratio and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1177/1479164118810691 | - |
dc.identifier.scopusid | 2-s2.0-85058990516 | - |
dc.identifier.wosid | 000465592900011 | - |
dc.identifier.bibliographicCitation | Diabetes and Vascular Disease Research, v.16, no.2, pp 186 - 195 | - |
dc.citation.title | Diabetes and Vascular Disease Research | - |
dc.citation.volume | 16 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 186 | - |
dc.citation.endPage | 195 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | METABOLIC-RESPONSE | - |
dc.subject.keywordPlus | BETA-CELL | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ULTRASONOGRAPHY | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | STEATOSIS | - |
dc.subject.keywordAuthor | Glucagon | - |
dc.subject.keywordAuthor | insulin | - |
dc.subject.keywordAuthor | glucagon-to-insulin ratio | - |
dc.subject.keywordAuthor | nonalcoholic fatty liver disease | - |
dc.subject.keywordAuthor | type 2 diabetes mellitus | - |
dc.subject.keywordAuthor | insulin resistance | - |
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