Association of glucagon-to-insulin ratio and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus
- Authors
- Moh, Myint Aung Moh; Jung, Chan-Hee; Lee, Bora; Choi, Dughyun; Kim, Bo-Yeon; Kim, Chul-Hee; Kang, Sung-Koo; Mok, Ji-Oh
- Issue Date
- Mar-2019
- Publisher
- SAGE Publications
- Keywords
- Glucagon; insulin; glucagon-to-insulin ratio; nonalcoholic fatty liver disease; type 2 diabetes mellitus; insulin resistance
- Citation
- Diabetes and Vascular Disease Research, v.16, no.2, pp 186 - 195
- Pages
- 10
- Journal Title
- Diabetes and Vascular Disease Research
- Volume
- 16
- Number
- 2
- Start Page
- 186
- End Page
- 195
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4667
- DOI
- 10.1177/1479164118810691
- ISSN
- 1479-1641
1752-8984
- Abstract
- Objective: The aim of this study is to investigate the association between glucagon-to-insulin ratio and the presence of nonalcoholic fatty liver disease on ultrasonography in participants with type 2 diabetes mellitus. Research design and methods: This cross-sectional study was performed with data obtained from 172 participants with type 2 diabetes mellitus admitted to a University hospital of Korea. Participants were assessed for serum fasting and postprandial serum glucagon-to-insulin ratio and divided into tertiles. Nonalcoholic fatty liver disease was defined as ultrasonographically detected fatty liver. Results: Prevalence of nonalcoholic fatty liver disease was significantly decreased across tertile of fasting and postprandial glucagon-to-insulin ratio (p = 0.009 for trend, p = 0.001 for trend, respectively). Lower glucagon-to-insulin ratio was significantly associated with the presence of nonalcoholic fatty liver disease even after adjustment for potential confounding variables [fasting glucagon-to-insulin ratio: odds ratio (95% confidence interval), 2.68 (1.08-6.86)], postprandial glucagon-to-insulin ratio: [2.72 (1.03-7.35)]. The participants in the lowest tertile of fasting glucagon-to-insulin ratio had higher body mass index, visceral fat thickness, subcutaneous fat thickness, homeostasis model assessment-insulin resistance and shorter duration of diabetes mellitus. Conclusion: This study suggests that lower glucagon relative insulin may be independently associated with nonalcoholic fatty liver disease in participants with type 2 diabetes.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
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