BILATERAL OVARIO-HYSTERECTOMY INDUCED OSTEOPOROTIC RABBIT MODEL
DC Field | Value | Language |
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dc.contributor.author | Jin, E. S. | - |
dc.contributor.author | Kim, J. Y. | - |
dc.contributor.author | Min, J. K. | - |
dc.contributor.author | Jeon, S. R. | - |
dc.contributor.author | Choi, K. H. | - |
dc.contributor.author | Lee, M. S. | - |
dc.contributor.author | Jeong, J. H. | - |
dc.date.accessioned | 2021-08-11T10:23:31Z | - |
dc.date.available | 2021-08-11T10:23:31Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 0393-974X | - |
dc.identifier.issn | 1724-6083 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4670 | - |
dc.description.abstract | Rabbit models have been proposed for the study of postmenopausal osteoporosis by bilateral ovariectomy with reduced dietary calcium intake or glucocorticoid administration. However, restricting dietary calcium intake or administering a glucocorticoid can cause secondary osteoporosis and is not representative of a pure postmenopausal osteoporosis model. The aim of this study was to establish an experimental rabbit model of osteoporosis induced by ovario-hysterectomy alone. Fourteen female New Zealand rabbits were separated into two groups of a sham (control) group and an ovario-hysterectomyinduced osteoporosis group. Tibiae were extracted 24 weeks after ovario-hysterectomy and were scanned by micro-computed tomography. The evaluation parameters were bone mineral density (BMD), trabecular bone volume (BV/TV), trabecular number (Tb.N), trabecular thickness, and trabecular separation (Tb.Sp). The tibial samples were evaluated after hematoxylin and eosin and Masson's trichrome staining. The sham group had significantly higher BMD, BV/TV, and Tb.N values and the lowest Tb.Sp value compared to the ovario-hysterectomy group. The histological analyses revealed a loss of the bony trabeculae and an increase in osteoporotic changes in the bone of the ovario-hysterectomy-induced osteoporosis group compared to the control group. Our results indicate that an ovario-hysterectomy-induced rabbit model would be a safe, reproducible model for postmenopausal osteoporosis studies. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Wichtig Publishing | - |
dc.title | BILATERAL OVARIO-HYSTERECTOMY INDUCED OSTEOPOROTIC RABBIT MODEL | - |
dc.type | Article | - |
dc.publisher.location | 이탈리아 | - |
dc.identifier.scopusid | 2-s2.0-85065143942 | - |
dc.identifier.wosid | 000464698500009 | - |
dc.identifier.bibliographicCitation | Journal of Biological Regulators and Homeostatic Agents, v.33, no.2, pp 391 - 396 | - |
dc.citation.title | Journal of Biological Regulators and Homeostatic Agents | - |
dc.citation.volume | 33 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 391 | - |
dc.citation.endPage | 396 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | OVARIECTOMY | - |
dc.subject.keywordPlus | OSSEOINTEGRATION | - |
dc.subject.keywordPlus | IMPLANTS | - |
dc.subject.keywordAuthor | animal model | - |
dc.subject.keywordAuthor | micro-computed tomography | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.subject.keywordAuthor | ovariectomy | - |
dc.subject.keywordAuthor | rabbit | - |
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