TSC2 genetic variant and prognosis in non-small cell lung cancer after curative surgeryopen access
- Authors
- Lee, Yong Hoon; Do, Sook Kyung; Lee, Shin Yup; Kang, Hyo-Gyoung; Choi, Jin Eun; Hong, Mi Jeong; Lee, Jang Hyuck; Lee, Eung Bae; Jeong, Ji Yun; Shin, Kyung Min; Lee, Won Kee; Seok, Yangki; Cho, Sukki; Yoo, Seung Soo; Lee, Jaehee; Cha, Seung Ick; Kim, Chang Ho; Jheon, Sanghoon; Park, Jae Yong
- Issue Date
- Feb-2019
- Publisher
- Blackwell Publishing Asia Pty Ltd
- Keywords
- Lung cancer; polymorphism; prognosis; TSC2
- Citation
- Thoracic Cancer, v.10, no.2, pp 335 - 340
- Pages
- 6
- Journal Title
- Thoracic Cancer
- Volume
- 10
- Number
- 2
- Start Page
- 335
- End Page
- 340
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4764
- DOI
- 10.1111/1759-7714.12951
- ISSN
- 1759-7706
1759-7714
- Abstract
- This study was conducted to investigate the associations between polymorphisms of genes involved in the LKB1 pathway and the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Twenty-three single nucleotide polymorphisms (SNPs) in the LKB1 pathway were investigated in 782 patients with NSCLC who underwent curative surgery. The association of SNPs with overall survival (OS) and disease-free survival (DFS) were analyzed. Among the 23 SNPs investigated, TSC2 rs30259G > A was associated with significantly worse OS and DFS (adjusted hazard ratio for OS 1.88, 95% confidence interval 1.21-2.91, P = 0.005; adjusted hazard ratio for DFS 1.65, 95% confidence interval 1.15-2.38, P = 0.01, under codominant models, respectively). Subgroup analysis showed that SNPs were significantly associated with survival outcomes in squamous cell carcinoma, ever-smokers, and stage I, but not in adenocarcinoma, never-smokers, and stage II-IIIA. The results suggest that TSC2 rs30259G > A may be useful to predict prognosis in patients with NSCLC, especially squamous cell carcinoma, after curative surgery.
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Collections - College of Medicine > Department of Cardiovascula Surgery > 1. Journal Articles
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