Clinical Characteristics of Oral Allergy Syndrome in Children with Atopic Dermatitis and Birch Sensitization: a Single Center Studyopen access
- Authors
- Kim, Kang-in; Lee, Bomi; Min, Taek Ki; Lee, Jeongho; Pyun, Bok Yang; Jeon, You Hoon
- Issue Date
- 14-Jan-2019
- Publisher
- 대한의학회
- Keywords
- Oral Allergy Syndrome; Children; Atopic Dermatitis; Birch
- Citation
- Journal of Korean Medical Science, v.34, no.2
- Journal Title
- Journal of Korean Medical Science
- Volume
- 34
- Number
- 2
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4788
- DOI
- 10.3346/jkms.2019.34.e11
- ISSN
- 1011-8934
1598-6357
- Abstract
- Background: Oral allergy syndrome (OAS) is an immunoglobulin E (IgE)-mediated hypersensitivity that occurs frequently in older children with pollen sensitization. This study focused on the clinical characteristics of OAS in children with atopic dermatitis (AD) and birch sensitization. Method: s: A total of 186 patients aged 2-18 years with AD and birch sensitization were enrolled in this study between January 2016 and March 2017. Their levels of serum total IgE and birch- and ragweed-specific IgE (sIgE) were measured using ImmunoCAP (Thermo Fisher Scientific, Uppsala, Sweden). Information regarding causative foods and symptoms were obtained via interviews. The patients were divided into 3 groups according to their ages group 1, 2-6 years; group 2, 7-12 years; and group 3, 13-18 years). Results: Eighty-one of the 186 (43.5%) children with AD who were sensitized to birch pollen were diagnosed as having OAS. The prevalence of OAS in group 1 (the children who had AD and birch sensitization aged 2-6 years) was 36.6%. A greater predominance of men was noted in the non-OAS group (77.1%) compared to the OAS group (60.5%). Apples were the most common causative food in group 2 and 3 while kiwis were the most common cause of OAS in group 1. There was a statistically significant correlation between birch-sIgE levels and the prevalence of OAS (P= 0.000). The cut-offvalue was 6.77 kU(A)/L with 55.6% sensitivity and 79.0% specificity (area tinder the curve 0.653). Conclusion: In our study, the prevalence of OAS in children with All and birch sensitization was 43.5%. Even in the preschool age group, the prevalence of OAS was considerable. Patients with high levels of birch-sIgE were more likely to have OAS. Clinicians should therefore be vigilant about OAS in patients with a high degree of sensitization to birch pollen and even young children if they have birch sensitization.
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